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Follicular lymphoma microenvironment characteristics associated with tumor cell mutations and MHC class II expression

Overview of attention for article published in Blood Cancer Discovery, June 2022
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#24 of 136)
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

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4 news outlets
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31 tweeters
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Title
Follicular lymphoma microenvironment characteristics associated with tumor cell mutations and MHC class II expression
Published in
Blood Cancer Discovery, June 2022
DOI 10.1158/2643-3230.bcd-21-0075
Pubmed ID
Authors

Han, Guangchun, Deng, Qing, Marques-Piubelli, Mario L., Dai, Enyu, Dang, Minghao, Ma, Man Chun John, Li, Xubin, Yang, Haopeng, Henderson, Jared, Kudryashova, Olga, Meerson, Mark, Isaev, Sergey, Kotlov, Nikita, Nomie, Krystle J., Bagaev, Alexander, Parra, Edwin R., Solis Soto, Luisa M., Parmar, Simrit, Hagemeister, Fredrick B., Ahmed, Sairah, Iyer, Swaminathan P., Samaniego, Felipe, Steiner, Raphael, Fayad, Luis, Lee, Hun, Fowler, Nathan H., Flowers, Christopher R., STRATI, PAOLO, Westin, Jason R., Neelapu, Sattva S., Nastoupil, Loretta J., Vega, Francisco, Wang, Linghua, Green, Michael R., Marques-Piubelli, Mario L, Nomie, Krystle J, Parra, Edwin R, Solis Soto, Luisa M, Hagemeister, Fredrick B, Iyer, Swaminathan P, Fowler, Nathan H, Flowers, Christopher R, Strati, Paolo, Westin, Jason R, Neelapu, Sattva S, Nastoupil, Loretta J, Green, Michael R

Abstract

Follicular lymphoma (FL) is a B-cell malignancy with a complex tumor microenvironment that is rich in non-malignant immune cells. We applied single-cell RNA-sequencing to characterize the diverse tumor and immune cell populations of FL and identified major phenotypic subsets of FL T-cells including a cytotoxic CD4 T-cell population. Their relative proportions of T-cells defined four major FL subtypes, characterized by differential representation or relative depletion of distinct T-cell subsets. By integrating exome sequencing, we observed that somatic mutations are associated with, but not definitive for, reduced MHC expression on FL cells. In turn, expression of MHC class II genes by FL cells was associated with significant differences in the proportions and targetable immunophenotypic characteristics of T-cells. This provides a classification framework of the FL microenvironment, their association with FL genotypes and MHC expression, and informs different potential immunotherapeutic strategies based upon tumor cell MHC class II expression.

Twitter Demographics

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Attention Score in Context

This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2022.
All research outputs
#681,835
of 21,421,530 outputs
Outputs from Blood Cancer Discovery
#24
of 136 outputs
Outputs of similar age
#10,544
of 241,265 outputs
Outputs of similar age from Blood Cancer Discovery
#2
of 9 outputs
Altmetric has tracked 21,421,530 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 136 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,265 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.