Constitutive activation of the tumor suppressor p53 in hepatocytes paradoxically promotes non-cell autonomous liver carcinogenesis.

Overview of attention for article published in Cancer Research, June 2022

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p53是癌症生物学中一种最重要的蛋白质，通常被称之为“基因组的守护者”，其会被激活用来对诸如DNA损伤等多种细胞压力产生反应。 p53是癌症生物学中一种最重要的蛋白质，通常被称之为“基因组的守护者”，其会被激活用来对诸如DNA损伤等多种细胞压力产生反应。p5…

撰文丨王聪编辑丨王多鱼排版丨水成文自1979年被发现以来， p53 基因一直是肿瘤学研究的焦点之一。在 Pubmed 数据库中用 p53 为关键词搜索，可以找到超过十万篇文献。在 Nature 杂志2017年的一项统计中，p53 基因以绝对优势位列过去…

CLD can be brought on by different factors including viruses, alcohol use, and fat accumulation, all of which can induce p53…

p53 is one of the most important proteins in cancer biology. Often referred to as a guardian of the genome, p53 becomes…

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