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Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome

Overview of attention for article published in Thrombosis Journal, October 2016
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Title
Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome
Published in
Thrombosis Journal, October 2016
DOI 10.1186/s12959-016-0115-z
Pubmed ID
Authors

Fatima El-Assaad, Steven A. Krilis, Bill Giannakopoulos

Abstract

The antiphospholipid syndrome (APS) is an autoimmune disease characterised by a procoagulant state that predisposes to recurrent thrombosis and miscarriages. Two major discoveries have advanced our understanding of the underlying complex pathogenesis of the APS. The first was the discovery that beta-2 glycoprotein-1 (β2GPI) is the major auto antigen in APS. The second was the discovery in more recent years that β2GPI contains allosteric disulphide bonds susceptible to posttranslational modification that may be involved in the development of autoantibodies in APS. The main allosteric disulphide bond in the fifth domain of β2GPI can exist in two redox states: free thiol or oxidised. It is the conformational transformation of β2GPI from its free thiol form to its more immunogenic oxidised form that exposes neo-epitopes on the first and fifth domains. The purpose of this review is to highlight the recent findings on the posttranslational forms of β2GPI in the pathogenesis of APS. We suggest that novel assays quantitating the different redox forms of β2GPI in plasma or serum may be used to supplement existing clinical and laboratory assays to more accurately stratify risk of thrombosis or miscarriage in APS patients.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 24%
Researcher 3 18%
Other 2 12%
Professor 1 6%
Student > Ph. D. Student 1 6%
Other 3 18%
Unknown 3 18%
Readers by discipline Count As %
Medicine and Dentistry 5 29%
Biochemistry, Genetics and Molecular Biology 3 18%
Immunology and Microbiology 1 6%
Energy 1 6%
Agricultural and Biological Sciences 1 6%
Other 1 6%
Unknown 5 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2016.
All research outputs
#5,745,105
of 7,591,700 outputs
Outputs from Thrombosis Journal
#66
of 92 outputs
Outputs of similar age
#163,131
of 235,116 outputs
Outputs of similar age from Thrombosis Journal
#5
of 6 outputs
Altmetric has tracked 7,591,700 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 92 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.7. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,116 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.