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Predictors of viral suppression and rebound among HIV-positive men who have sex with men in a large multi-site Canadian cohort

Overview of attention for article published in BMC Infectious Diseases, October 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

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7 tweeters
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1 Facebook page

Citations

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14 Dimensions

Readers on

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32 Mendeley
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Title
Predictors of viral suppression and rebound among HIV-positive men who have sex with men in a large multi-site Canadian cohort
Published in
BMC Infectious Diseases, October 2016
DOI 10.1186/s12879-016-1926-z
Pubmed ID
Authors

Zachary Tanner, Nathan Lachowsky, Erin Ding, Hasina Samji, Mark Hull, Angela Cescon, Sophie Patterson, Jason Chia, Alia Leslie, Janet Raboud, Mona Loutfy, Curtis Cooper, Marina Klein, Nima Machouf, Christos Tsoukas, Julio Montaner, Robert S. Hogg

Abstract

Gay, bisexual and other men who have sex with men (MSM) are disproportionately affected by HIV in Canada. Combination antiretroviral therapy has been shown to dramatically decrease progression to AIDS, premature death and HIV transmission. However, there are no comprehensive data regarding combination antiretroviral therapy outcomes among this population. We sought to identify socio-demographic and clinical correlates of viral suppression and rebound. Our analysis included MSM participants in the Canadian Observational Cohort, a multi-site cohort of HIV-positive adults from Canada's three most populous provinces, aged ≥18 years who first initiated combination antiretroviral therapy between 2000 and 2011. We used accelerated failure time models to identify factors predicting time to suppression (2 measures <50 copies/mL ≥30 days apart) and subsequent rebound (2 measures >200 copies/mL ≥30 days apart). Of 2,858 participants, 2,448 (86 %) achieved viral suppression in a median time of 5 months (Q1-Q3: 3-7 months). Viral suppression was significantly associated with later calendar year of antiretroviral therapy initiation, no history of injection drug use, lower baseline viral load, being on an initial regimen consisting of non-nucleoside reverse-transcriptase inhibitors, and older age. Among those who suppressed, 295 (12 %) experienced viral rebound. This was associated with earlier calendar year of antiretroviral therapy initiation, injection drug use history, younger age, higher baseline CD4 cell count, and living in British Columbia. Further strategies are required to optimize combination antiretroviral therapy outcomes in men who have sex with men in Canada, specifically targeting younger MSM and those with a history of injection drug use.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 25%
Unspecified 7 22%
Student > Master 5 16%
Student > Ph. D. Student 4 13%
Student > Doctoral Student 3 9%
Other 5 16%
Readers by discipline Count As %
Medicine and Dentistry 10 31%
Unspecified 8 25%
Nursing and Health Professions 4 13%
Psychology 4 13%
Social Sciences 3 9%
Other 3 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2016.
All research outputs
#2,007,391
of 8,617,495 outputs
Outputs from BMC Infectious Diseases
#826
of 3,828 outputs
Outputs of similar age
#77,654
of 249,754 outputs
Outputs of similar age from BMC Infectious Diseases
#45
of 226 outputs
Altmetric has tracked 8,617,495 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,828 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,754 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 226 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.