Chapter title |
Antibiotic Treatment of Hospitalized Patients with Pneumonia Complicated by Clostridium Difficile Infection.
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Chapter number | 72 |
Book title |
Advancements in Clinical Research
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Published in |
Advances in experimental medicine and biology, September 2016
|
DOI | 10.1007/5584_2016_72 |
Pubmed ID | |
Book ISBNs |
978-3-31-948032-9, 978-3-31-948033-6
|
Authors |
K. Zycinska, M. Chmielewska, B. Lenartowicz, M. Hadzik-Blaszczyk, M. Cieplak, Z. Kur, R. Krupa, K. A. Wardyn |
Editors |
Mieczyslaw Pokorski |
Abstract |
Clostridium difficile infection (CDI) is one of the most common gastrointestinal complication after antimicrobial treatment. It is estimated that CDI after pneumonia treatment is connected with a higher mortality than other causes of hospitalization. The aim of the study was to assess the relationship between the kind of antibiotic used for pneumonia treatment and mortality from post-pneumonia CDI. We addressed the issue by examining retrospectively the records of 217 patients who met the diagnostic criteria of CDI. Ninety four of those patients (43.3 %) came down with CDI infection after pneumonia treatment. Fifty of the 94 patients went through severe or severe and complicated CDI. The distribution of antecedent antibiotic treatment of pneumonia in these 50 patients was as follows: ceftriaxone in 14 (28 %) cases, amoxicillin with clavulanate in 9 (18 %), ciprofloxacin in 8 (16.0 %), clarithromycin in 7 (14 %), and cefuroxime and imipenem in 6 (12 %) each. The findings revealed a borderline enhancement in the proportion of deaths due to CDI in the ceftriaxone group compared with the ciprofloxacin, cefuroxime, and imipenem groups. The corollary is that ceftriaxone should be shunned in pneumonia treatment. The study demonstrates an association between the use of a specific antibiotic for pneumonia treatment and post-pneumonia mortality in patients who developed CDI. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 2 | 14% |
Unspecified | 1 | 7% |
Professor | 1 | 7% |
Student > Bachelor | 1 | 7% |
Student > Master | 1 | 7% |
Other | 1 | 7% |
Unknown | 7 | 50% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 14% |
Veterinary Science and Veterinary Medicine | 1 | 7% |
Computer Science | 1 | 7% |
Unspecified | 1 | 7% |
Physics and Astronomy | 1 | 7% |
Other | 1 | 7% |
Unknown | 7 | 50% |