Title |
Developmental timing and critical windows for the treatment of psychiatric disorders
|
---|---|
Published in |
Nature Medicine, October 2016
|
DOI | 10.1038/nm.4225 |
Pubmed ID | |
Authors |
Oscar Marín |
Abstract |
There is a growing understanding that pathological genetic variation and environmental insults during sensitive periods in brain development have long-term consequences on brain function, which range from learning disabilities to complex psychiatric disorders such as schizophrenia. Furthermore, recent experiments in animal models suggest that therapeutic interventions during sensitive periods, typically before the onset of clear neurological and behavioral symptoms, might prevent or ameliorate the development of specific pathologies. These studies suggest that understanding the dynamic nature of the pathophysiological mechanisms underlying psychiatric disorders is crucial for the development of effective therapies. In this Perspective, I explore the emerging concept of developmental windows in psychiatric disorders, their relevance for understanding disease progression and their potential for the design of new therapies. The limitations and caveats of early interventions in psychiatric disorders are also discussed in this context. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 10 | 18% |
United States | 9 | 16% |
Australia | 6 | 11% |
Spain | 4 | 7% |
South Africa | 2 | 4% |
Netherlands | 2 | 4% |
Germany | 2 | 4% |
Canada | 2 | 4% |
Israel | 1 | 2% |
Other | 3 | 5% |
Unknown | 14 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 28 | 51% |
Scientists | 18 | 33% |
Practitioners (doctors, other healthcare professionals) | 6 | 11% |
Science communicators (journalists, bloggers, editors) | 3 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
United States | 1 | <1% |
France | 1 | <1% |
Austria | 1 | <1% |
Unknown | 540 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 100 | 18% |
Student > Ph. D. Student | 95 | 17% |
Student > Master | 57 | 10% |
Student > Bachelor | 41 | 8% |
Student > Doctoral Student | 33 | 6% |
Other | 106 | 19% |
Unknown | 112 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 148 | 27% |
Agricultural and Biological Sciences | 76 | 14% |
Medicine and Dentistry | 45 | 8% |
Psychology | 41 | 8% |
Biochemistry, Genetics and Molecular Biology | 38 | 7% |
Other | 52 | 10% |
Unknown | 144 | 26% |