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AMP-activated Protein Kinase Activation by 5-Aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside (AICAR) Reduces Lipoteichoic Acid-induced Lung Inflammation

Overview of attention for article published in Journal of Biological Chemistry, January 2013
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Citations

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5 Mendeley
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Title
AMP-activated Protein Kinase Activation by 5-Aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside (AICAR) Reduces Lipoteichoic Acid-induced Lung Inflammation
Published in
Journal of Biological Chemistry, January 2013
DOI 10.1074/jbc.m112.413138
Pubmed ID
Authors

Hoogendijk AJ, Pinhanços SS, van der Poll T, Wieland CW, Arie J. Hoogendijk, Sandra S. Pinhanços, Tom van der Poll, Catharina W. Wieland

Abstract

Adenosine monophosphate-activated protein (AMP)-activated kinase (AMPK) is a highly conserved kinase that plays a key role in energy homeostasis. Activation of AMPK was shown to reduce inflammation in response to lipolysaccharide in vitro and in vivo. 5-Aminoimidazole-4-carbox-amide-1-β-D-ribofuranoside (AICAR) is intracellularly converted to the AMP analog ZMP, which activates AMPK. Lipoteichoic acid (LTA) is a major component of the cell wall of Gram-positive bacteria that can trigger inflammatory responses. In contrast to lipopolysaccharide, little is known on the effects of AMPK activation in LTA-triggered innate immune responses. Here, we studied the potency of AMPK activation to reduce LTA-induced inflammation in vitro and in lungs in vivo. Activation of AMPK in vitro reduced cytokine production in the alveolar macrophage cell line MH-S. In vivo, AMPK activation reduced LTA-induced neutrophil influx, as well as protein leak and cytokine/chemokine levels in the bronchoalveolar space. In conclusion, AMPK activation inhibits LTA-induced lung inflammation in mice.

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 20%
Unknown 4 80%

Demographic breakdown

Readers by professional status Count As %
Unspecified 2 40%
Student > Bachelor 1 20%
Other 1 20%
Student > Ph. D. Student 1 20%
Readers by discipline Count As %
Unspecified 2 40%
Agricultural and Biological Sciences 2 40%
Immunology and Microbiology 1 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2013.
All research outputs
#4,573,135
of 8,542,489 outputs
Outputs from Journal of Biological Chemistry
#21,900
of 31,322 outputs
Outputs of similar age
#58,921
of 120,176 outputs
Outputs of similar age from Journal of Biological Chemistry
#21
of 56 outputs
Altmetric has tracked 8,542,489 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,322 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,176 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.