Genome remodelling in a basal-like breast cancer metastasis and xenograft

Overview of attention for article published in Nature, April 2010

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乳癌原発巣・脳転移・移植片の遺伝子変異パターンを比較すると原発巣は他の2つに比べて明らかに多様なクローンからなり、何らかの選択圧により特定の変異を持つ腫瘍細胞だけが転移先に生着しうる。原発巣は変異多様性を持ち、転移先は比較的均一な集団。 http://t.co/8rg9N41z

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