↓ Skip to main content

A Variant in LIN28B Is Associated with 2D:4D Finger-Length Ratio, a Putative Retrospective Biomarker of Prenatal Testosterone Exposure

Overview of attention for article published in American Journal of Human Genetics, April 2010
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

blogs
1 blog
f1000
1 research highlight platform

Citations

dimensions_citation
65 Dimensions

Readers on

mendeley
76 Mendeley
citeulike
1 CiteULike
connotea
1 Connotea
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
A Variant in LIN28B Is Associated with 2D:4D Finger-Length Ratio, a Putative Retrospective Biomarker of Prenatal Testosterone Exposure
Published in
American Journal of Human Genetics, April 2010
DOI 10.1016/j.ajhg.2010.02.017
Pubmed ID
Authors

Sarah E. Medland, Tetyana Zayats, Beate Glaser, Dale R. Nyholt, Scott D. Gordon, Margaret J. Wright, Grant W. Montgomery, Megan J. Campbell, Anjali K. Henders, Nicholas J. Timpson, Leena Peltonen, Dieter Wolke, Susan M. Ring, Panos Deloukas, Nicholas G. Martin, George Davey Smith, David M. Evans

Abstract

The ratio of the lengths of an individual's second to fourth digit (2D:4D) is commonly used as a noninvasive retrospective biomarker for prenatal androgen exposure. In order to identify the genetic determinants of 2D:4D, we applied a genome-wide association approach to 1507 11-year-old children from the Avon Longitudinal Study of Parents and Children (ALSPAC) in whom 2D:4D ratio had been measured, as well as a sample of 1382 12- to 16-year-olds from the Brisbane Adolescent Twin Study. A meta-analysis of the two scans identified a single variant in the LIN28B gene that was strongly associated with 2D:4D (rs314277: p = 4.1 x 10(-8)) and was subsequently independently replicated in an additional 3659 children from the ALSPAC cohort (p = 1.53 x 10(-6)). The minor allele of the rs314277 variant has previously been linked to increased height and delayed age at menarche, but in our study it was associated with increased 2D:4D in the direction opposite to that of previous reports on the correlation between 2D:4D and age at menarche. Our findings call into question the validity of 2D:4D as a simplistic retrospective biomarker for prenatal testosterone exposure.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 4%
United States 2 3%
Canada 1 1%
Unknown 70 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 24%
Student > Ph. D. Student 14 18%
Student > Bachelor 8 11%
Unspecified 7 9%
Professor 6 8%
Other 23 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 26%
Medicine and Dentistry 19 25%
Psychology 14 18%
Unspecified 6 8%
Social Sciences 6 8%
Other 11 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2013.
All research outputs
#1,277,542
of 12,343,107 outputs
Outputs from American Journal of Human Genetics
#913
of 4,389 outputs
Outputs of similar age
#1,239,764
of 11,734,338 outputs
Outputs of similar age from American Journal of Human Genetics
#909
of 4,278 outputs
Altmetric has tracked 12,343,107 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,389 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.5. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 11,734,338 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 4,278 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.