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Towards translational rodent models of depression

Overview of attention for article published in Cell and Tissue Research, March 2013
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Title
Towards translational rodent models of depression
Published in
Cell and Tissue Research, March 2013
DOI 10.1007/s00441-013-1587-9
Pubmed ID
Authors

Olivia F. O’Leary, John F. Cryan

Abstract

Rodent models of depression have been developed in an effort to identify novel antidepressant compounds and to further our understanding of the pathophysiology of depression. Various rodent models of depression and antidepressant-like behaviour are currently used but, clearly, none of these current models fully recapitulate all features of depression. Moreover, these models have not resulted in the development of novel non-monoaminergic-based antidepressants with clinical efficacy. Thus, a refinement of the current models of depression is required. The present review outlines the most commonly used models of depression and antidepressant drug-like activity and suggests several factors that should be considered when refining these models.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ireland 1 <1%
Canada 1 <1%
South Africa 1 <1%
Unknown 118 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 19%
Researcher 17 14%
Student > Bachelor 15 12%
Student > Master 9 7%
Student > Doctoral Student 6 5%
Other 21 17%
Unknown 30 25%
Readers by discipline Count As %
Neuroscience 23 19%
Agricultural and Biological Sciences 23 19%
Medicine and Dentistry 14 12%
Psychology 9 7%
Biochemistry, Genetics and Molecular Biology 4 3%
Other 11 9%
Unknown 37 31%