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Comparing the angiogenic potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells

Overview of attention for article published in Journal of Translational Medicine, March 2013
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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2 X users
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1 patent

Citations

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30 Dimensions

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Title
Comparing the angiogenic potency of naïve marrow stromal cells and Notch-transfected marrow stromal cells
Published in
Journal of Translational Medicine, March 2013
DOI 10.1186/1479-5876-11-81
Pubmed ID
Authors

Mo Dao, Ciara C Tate, Michael McGrogan, Casey C Case

Abstract

Angiogenesis is a critical part of the endogenous repair process in brain injury and disease, and requires at least two sequential steps. First, angiogenic sprouting of endothelial cells occurs, which entails the initial proliferation of endothelial cells and remodeling of the surrounding extracellular matrix. Second, vessel stabilization is necessary to prevent vascular regression, which relies on vascular smooth muscle recruitment to surround the young vessels. Marrow stromal cells (MSCs) have been shown to promote revascularization after hindlimb ischemia, cardiac ischemia, and stroke. SB623 cells are derived from marrow stromal cells by transfection with a Notch1 intracellular domain (NICD)-expressing plasmid and are known to elicit functional improvement in experimental stroke. These cells are currently used in human clinical testing for treatment of chronic stroke. In the current study, the angiogenic property of SB623 cells was investigated using cell-based assays.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
United States 1 3%
Italy 1 3%
Unknown 26 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 21%
Researcher 5 17%
Student > Bachelor 3 10%
Student > Doctoral Student 2 7%
Other 2 7%
Other 7 24%
Unknown 4 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 24%
Medicine and Dentistry 7 24%
Biochemistry, Genetics and Molecular Biology 3 10%
Neuroscience 3 10%
Psychology 1 3%
Other 3 10%
Unknown 5 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2018.
All research outputs
#7,218,579
of 23,867,274 outputs
Outputs from Journal of Translational Medicine
#1,133
of 4,236 outputs
Outputs of similar age
#59,156
of 200,261 outputs
Outputs of similar age from Journal of Translational Medicine
#23
of 56 outputs
Altmetric has tracked 23,867,274 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 4,236 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,261 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.