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MicroRNA miR-24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1and p16INK4a

Overview of attention for article published in Journal of Cellular Physiology, June 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

twitter
1 tweeter
patent
1 patent

Citations

dimensions_citation
50 Dimensions

Readers on

mendeley
15 Mendeley
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Title
MicroRNA miR-24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1and p16INK4a
Published in
Journal of Cellular Physiology, June 2013
DOI 10.1002/jcp.24368
Pubmed ID
Authors

Simona Giglio, Roberto Cirombella, Rachele Amodeo, Luciano Portaro, Luca Lavra, Andrea Vecchione

Abstract

Cell cycle progression is controlled by numerous mechanisms ensuring correct cell division. The transition from one cell cycle phase to another occurs in an orderly fashion and is regulated by different cellular proteins. Therefore an alteration of the regulatory mechanisms of the cell cycle results in uncontrolled cell proliferation, which is a distinctive feature of human cancers. Recent evidences suggest that microRNAs (miRs) may also control the levels of multiple cell cycle regulators and therefore control cell proliferation. In fact miRs are a class of small non-coding RNAs, which modulate gene expression. They are involved in numerous physiological cellular processes and most importantly accumulating evidence indicates that many miRs are aberrantly expressed in human cancers. In this report we describe that miR-24 directly targets p27(Kip1) and p16(Ink4a) in primary keratinocyte and in different cancer derived cell lines promoting their proliferation, suggesting that miR-24 is involved in cyclin-dependent kinase inhibitors post-transcriptional regulation and that upregulation of miR-24 may play a role in carcinogenesis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 27%
Student > Master 3 20%
Student > Ph. D. Student 3 20%
Professor 2 13%
Student > Doctoral Student 1 7%
Other 1 7%
Unknown 1 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 33%
Agricultural and Biological Sciences 4 27%
Computer Science 2 13%
Medicine and Dentistry 2 13%
Immunology and Microbiology 1 7%
Other 0 0%
Unknown 1 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2019.
All research outputs
#4,301,409
of 14,860,150 outputs
Outputs from Journal of Cellular Physiology
#829
of 4,876 outputs
Outputs of similar age
#42,448
of 152,291 outputs
Outputs of similar age from Journal of Cellular Physiology
#4
of 41 outputs
Altmetric has tracked 14,860,150 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 4,876 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 152,291 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.