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Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats

Overview of attention for article published in Pain (03043959), April 2013
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Title
Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats
Published in
Pain (03043959), April 2013
DOI 10.1016/j.pain.2012.12.021
Pubmed ID
Authors

Kieran Rea, Weredeselam M. Olango, Brendan Harhen, Daniel M. Kerr, Rachel Galligan, Sean Fitzgerald, Maeve Moore, Michelle Roche, David P. Finn

Abstract

The basolateral amygdala (BLA) is a key substrate facilitating the expression of fear-conditioned analgesia (FCA). However, the neurochemical mechanisms in the BLA which mediate this potent suppression of pain responding during fear remain unknown. The present study investigated the role of cannabinoid1 (CB1) receptors and interactions with GABAergic (GABAA receptor) and glutamatergic (metabotropic glutamate receptor type 5; mGluR5) signalling in the BLA in formalin-evoked nociceptive behaviour and FCA in rats. Reexposure to a context previously paired with foot shock significantly reduced formalin-evoked nociceptive behaviour. Systemic or intra-BLA microinjection of the CB1 receptor antagonist/inverse agonist AM251 prevented this expression of FCA, while injection of AM251 into the central nucleus of the amygdala did not. The suppression of FCA by systemic AM251 administration was partially attenuated by intra-BLA administration of either the GABAA receptor antagonist bicuculline or the mGluR5 antagonist 2-methyl-6-(phenylethynyl) pyridine, (MPEP). Bilateral microinjection of MPEP, but not bicuculline, alone into the BLA enhanced formalin-evoked nociceptive behaviour. Postmortem analyses revealed that FCA was associated with a significant increase in tissue levels of anandamide in the BLA side contralateral to intraplantar formalin injection. In addition, fear-conditioned rats exhibited a robust formalin-induced increase in levels of 2-arachidonyl glycerol and N-palmitoylethanolamide in the ipsilateral and contralateral BLA, respectively. These data suggest that CB1 receptors in the BLA facilitate the expression of FCA, through a mechanism which is likely to involve the modulation of GABAergic and glutamatergic signalling.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
United Kingdom 1 2%
Germany 1 2%
Unknown 48 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 27%
Student > Bachelor 9 17%
Researcher 6 12%
Professor 6 12%
Student > Doctoral Student 3 6%
Other 10 19%
Unknown 4 8%
Readers by discipline Count As %
Medicine and Dentistry 14 27%
Neuroscience 13 25%
Agricultural and Biological Sciences 11 21%
Biochemistry, Genetics and Molecular Biology 3 6%
Psychology 2 4%
Other 4 8%
Unknown 5 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2013.
All research outputs
#2,932,813
of 4,507,211 outputs
Outputs from Pain (03043959)
#1,812
of 2,423 outputs
Outputs of similar age
#56,888
of 89,346 outputs
Outputs of similar age from Pain (03043959)
#61
of 70 outputs
Altmetric has tracked 4,507,211 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,423 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 89,346 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.