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CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial

Overview of attention for article published in Trials, June 2012
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Title
CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial
Published in
Trials, June 2012
DOI 10.1186/1745-6215-13-87
Pubmed ID
Authors

Yashbir Dewan, Edward O Komolafe, Jorge H Mejía-Mantilla, Pablo Perel, Ian Roberts, Haleema Shakur

Abstract

Worldwide, over 10 million people are killed or hospitalized because of traumatic brain injury each year. About 90% of deaths occur in low- and middle-income countries. The condition mostly affects young adults, and many experience long lasting or permanent disability. The social and economic burden is considerable. Tranexamic acid (TXA) is commonly given to surgical patients to reduce bleeding and the need for blood transfusion. It has been shown to reduce the number of patients receiving a blood transfusion by about a third, reduces the volume of blood transfused by about one unit, and halves the need for further surgery to control bleeding in elective surgical patients.

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Mendeley readers

The data shown below were compiled from readership statistics for 293 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Japan 2 <1%
Brazil 1 <1%
Australia 1 <1%
Mexico 1 <1%
Unknown 285 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 49 17%
Other 33 11%
Student > Master 32 11%
Researcher 31 11%
Student > Postgraduate 22 8%
Other 65 22%
Unknown 61 21%
Readers by discipline Count As %
Medicine and Dentistry 153 52%
Nursing and Health Professions 22 8%
Agricultural and Biological Sciences 11 4%
Psychology 8 3%
Neuroscience 4 1%
Other 20 7%
Unknown 75 26%