Mutational signatures associated with tobacco smoking in human cancer

Overview of attention for article published in Science, November 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#15 of 39,076)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
206 news outlets
blogs
8 blogs
twitter
729 tweeters
peer_reviews
1 peer review site
facebook
26 Facebook pages
googleplus
11 Google+ users
reddit
1 Redditor

Readers on

mendeley
219 Mendeley
citeulike
11 CiteULike
Title
Mutational signatures associated with tobacco smoking in human cancer
Published in
Science, November 2016
DOI 10.1126/science.aag0299
Pubmed ID
Authors

Ludmil B. Alexandrov, Young Seok Ju, Kerstin Haase, Peter Van Loo, Iñigo Martincorena, Serena Nik-Zainal, Yasushi Totoki, Akihiro Fujimoto, Hidewaki Nakagawa, Tatsuhiro Shibata, Peter J. Campbell, Paolo Vineis, David H. Phillips, Michael R. Stratton, Alexandrov, Ludmil B, Ju, Young Seok, Haase, Kerstin, Van Loo, Peter, Martincorena, Iñigo, Nik-Zainal, Serena, Totoki, Yasushi, Fujimoto, Akihiro, Nakagawa, Hidewaki, Shibata, Tatsuhiro, Campbell, Peter J, Vineis, Paolo, Phillips, David H, Stratton, Michael R

Abstract

Tobacco smoking increases the risk of at least 17 classes of human cancer. We analyzed somatic mutations and DNA methylation in 5243 cancers of types for which tobacco smoking confers an elevated risk. Smoking is associated with increased mutation burdens of multiple distinct mutational signatures, which contribute to different extents in different cancers. One of these signatures, mainly found in cancers derived from tissues directly exposed to tobacco smoke, is attributable to misreplication of DNA damage caused by tobacco carcinogens. Others likely reflect indirect activation of DNA editing by APOBEC cytidine deaminases and of an endogenous clocklike mutational process. Smoking is associated with limited differences in methylation. The results are consistent with the proposition that smoking increases cancer risk by increasing the somatic mutation load, although direct evidence for this mechanism is lacking in some smoking-related cancer types.

Twitter Demographics

The data shown below were collected from the profiles of 729 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 219 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 5 2%
United States 4 2%
Germany 2 <1%
France 2 <1%
Brazil 2 <1%
Denmark 2 <1%
India 1 <1%
Poland 1 <1%
China 1 <1%
Other 3 1%
Unknown 196 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 67 31%
Student > Ph. D. Student 56 26%
Student > Bachelor 28 13%
Other 14 6%
Student > Master 13 6%
Other 41 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 98 45%
Biochemistry, Genetics and Molecular Biology 45 21%
Medicine and Dentistry 38 17%
Computer Science 7 3%
Social Sciences 4 2%
Other 27 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 2220. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2017.
All research outputs
#171
of 7,416,769 outputs
Outputs from Science
#15
of 39,076 outputs
Outputs of similar age
#12
of 227,594 outputs
Outputs of similar age from Science
#1
of 1,022 outputs
Altmetric has tracked 7,416,769 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 39,076 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,594 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,022 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.