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Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

Overview of attention for article published in Current Neuropharmacology, March 2009
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#4 of 599)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
14 news outlets
blogs
2 blogs
twitter
25 tweeters
patent
10 patents
facebook
6 Facebook pages
googleplus
2 Google+ users
video
5 video uploaders

Citations

dimensions_citation
1715 Dimensions

Readers on

mendeley
1587 Mendeley
citeulike
2 CiteULike
connotea
1 Connotea
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Title
Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options
Published in
Current Neuropharmacology, March 2009
DOI 10.2174/157015909787602823
Pubmed ID
Authors

Bayani Uttara, Ajay Singh, Paolo Zamboni, R. Mahajan

Abstract

Free radicals are common outcome of normal aerobic cellular metabolism. In-built antioxidant system of body plays its decisive role in prevention of any loss due to free radicals. However, imbalanced defense mechanism of antioxidants, overproduction or incorporation of free radicals from environment to living system leads to serious penalty leading to neuro-degeneration. Neural cells suffer functional or sensory loss in neurodegenerative diseases. Apart from several other environmental or genetic factors, oxidative stress (OS) leading to free radical attack on neural cells contributes calamitous role to neuro-degeneration. Though, oxygen is imperative for life, imbalanced metabolism and excess reactive oxygen species (ROS) generation end into a range of disorders such as Alzheimer's disease, Parkinson's disease, aging and many other neural disorders. Toxicity of free radicals contributes to proteins and DNA injury, inflammation, tissue damage and subsequent cellular apoptosis. Antioxidants are now being looked upon as persuasive therapeutic against solemn neuronal loss, as they have capability to combat by neutralizing free radicals. Diet is major source of antioxidants, as well as medicinal herbs are catching attention to be commercial source of antioxidants at present. Recognition of upstream and downstream antioxidant therapy to oxidative stress has been proved an effective tool in alteration of any neuronal damage as well as free radical scavenging. Antioxidants have a wide scope to sequester metal ions involved in neuronal plaque formation to prevent oxidative stress. In addition, antioxidant therapy is vital in scavenging free radicals and ROS preventing neuronal degeneration in post-oxidative stress scenario.

Twitter Demographics

The data shown below were collected from the profiles of 25 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,587 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 7 <1%
India 4 <1%
United States 4 <1%
Spain 4 <1%
Mexico 3 <1%
China 2 <1%
Ireland 2 <1%
Turkey 2 <1%
Portugal 2 <1%
Other 16 1%
Unknown 1541 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 354 22%
Student > Bachelor 307 19%
Student > Master 281 18%
Researcher 135 9%
Student > Doctoral Student 104 7%
Other 222 14%
Unknown 184 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 397 25%
Biochemistry, Genetics and Molecular Biology 210 13%
Medicine and Dentistry 173 11%
Chemistry 136 9%
Neuroscience 107 7%
Other 309 19%
Unknown 255 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 152. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2020.
All research outputs
#133,741
of 16,062,610 outputs
Outputs from Current Neuropharmacology
#4
of 599 outputs
Outputs of similar age
#1,094
of 155,738 outputs
Outputs of similar age from Current Neuropharmacology
#1
of 11 outputs
Altmetric has tracked 16,062,610 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 599 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,738 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.