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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology
|
|---|---|
| Published in |
Nature Communications, November 2016
|
| DOI | 10.1038/ncomms13249 |
| Pubmed ID | |
| Authors |
Taylor W. Schmitz, R. Nathan Spreng |
| Abstract |
There is considerable debate whether Alzheimer's disease (AD) originates in basal forebrain or entorhinal cortex. Here we examined whether longitudinal decreases in basal forebrain and entorhinal cortex grey matter volume were interdependent and sequential. In a large cohort of age-matched older adults ranging from cognitively normal to AD, we demonstrate that basal forebrain volume predicts longitudinal entorhinal degeneration. Models of parallel degeneration or entorhinal origin received negligible support. We then integrated volumetric measures with an amyloid biomarker sensitive to pre-symptomatic AD pathology. Comparison between cognitively matched normal adult subgroups, delineated according to the amyloid biomarker, revealed abnormal degeneration in basal forebrain, but not entorhinal cortex. Abnormal degeneration in both basal forebrain and entorhinal cortex was only observed among prodromal (mildly amnestic) individuals. We provide evidence that basal forebrain pathology precedes and predicts both entorhinal pathology and memory impairment, challenging the widely held belief that AD has a cortical origin. |
X Demographics
The data shown below were collected from the profiles of 62 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 9 | 15% |
| United States | 8 | 13% |
| Canada | 4 | 6% |
| Brazil | 3 | 5% |
| Spain | 2 | 3% |
| Taiwan | 1 | 2% |
| Norway | 1 | 2% |
| Germany | 1 | 2% |
| Sweden | 1 | 2% |
| Other | 5 | 8% |
| Unknown | 27 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 41 | 66% |
| Scientists | 14 | 23% |
| Practitioners (doctors, other healthcare professionals) | 5 | 8% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 369 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| United Kingdom | 1 | <1% |
| Norway | 1 | <1% |
| Spain | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 360 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 82 | 22% |
| Researcher | 55 | 15% |
| Student > Master | 41 | 11% |
| Student > Bachelor | 40 | 11% |
| Student > Doctoral Student | 19 | 5% |
| Other | 61 | 17% |
| Unknown | 71 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 109 | 30% |
| Psychology | 38 | 10% |
| Medicine and Dentistry | 34 | 9% |
| Agricultural and Biological Sciences | 32 | 9% |
| Biochemistry, Genetics and Molecular Biology | 17 | 5% |
| Other | 44 | 12% |
| Unknown | 95 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 165. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2018.
All research outputs
#246,311
of 25,402,889 outputs
Outputs from Nature Communications
#3,570
of 56,993 outputs
Outputs of similar age
#4,824
of 317,476 outputs
Outputs of similar age from Nature Communications
#84
of 940 outputs
Altmetric has tracked 25,402,889 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 56,993 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,476 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 940 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.