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Efficient CD44-targeted magnetic resonance imaging (MRI) of breast cancer cells using hyaluronic acid (HA)-modified MnFe2O4 nanocrystals

Overview of attention for article published in Nanoscale Research Letters, January 2013
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Title
Efficient CD44-targeted magnetic resonance imaging (MRI) of breast cancer cells using hyaluronic acid (HA)-modified MnFe2O4 nanocrystals
Published in
Nanoscale Research Letters, January 2013
DOI 10.1186/1556-276x-8-149
Pubmed ID
Authors

Taeksu Lee, Eun-Kyung Lim, Jaemin Lee, Byunghoon Kang, Jihye Choi, Hyo Seon Park, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam

Abstract

Targeted molecular imaging with hyaluronic acid (HA) has been highlighted in the diagnosis and treatment of CD44-overexpressing cancer. CD44, a receptor for HA, is closely related to the growth of cancer including proliferation, metastasis, invasion, and angiogenesis. For the efficient detection of CD44, we fabricated a few kinds of HA-modified MnFe2O4 nanocrystals (MNCs) to serve as specific magnetic resonance (MR) contrast agents (HA-MRCAs) and compared physicochemical properties, biocompatibility, and the CD44 targeting efficiency. Hydrophobic MNCs were efficiently phase-transferred using aminated polysorbate 80 (P80) synthesized by introducing spermine molecules on the hydroxyl groups of P80. Subsequently, a few kinds of HA-MRCAs were fabricated, conjugating different ratios of HA on the equal amount of phase-transferred MNCs. The optimized conjugation ratio of HA against magnetic content was identified to exhibit not only effective CD44 finding ability but also high cell viability through in vitro experiments. The results of this study demonstrate that the suggested HA-MRCA shows strong potential to be used for accurate tumor diagnosis.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 4%
Canada 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 33%
Researcher 7 26%
Student > Postgraduate 3 11%
Unspecified 2 7%
Student > Master 1 4%
Other 5 19%
Readers by discipline Count As %
Medicine and Dentistry 6 22%
Chemistry 5 19%
Agricultural and Biological Sciences 4 15%
Unspecified 4 15%
Pharmacology, Toxicology and Pharmaceutical Science 4 15%
Other 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2013.
All research outputs
#2,904,309
of 3,628,216 outputs
Outputs from Nanoscale Research Letters
#89
of 380 outputs
Outputs of similar age
#66,010
of 85,485 outputs
Outputs of similar age from Nanoscale Research Letters
#1
of 2 outputs
Altmetric has tracked 3,628,216 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 380 research outputs from this source. They receive a mean Attention Score of 0.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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