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Mendeley readers
Attention Score in Context
| Title |
Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans
|
|---|---|
| Published in |
Immunity & Ageing, January 2013
|
| DOI | 10.1186/1742-4933-10-3 |
| Pubmed ID | |
| Authors |
Sudhir Gupta, Sudhanshu Agrawal, Sastry Gollapudi |
| Abstract |
Aging is associated chronic inflammation and autoimmunity, and increased levels of leptin. Increased levels of leptin are associated with inflammation and autoimmunity. We have recently reported that leptin activates B cells to induce secretion of proinflammatory and anti-inflammatory cytokines. Role of B cells and leptin in inflammation associated with aging has not been explored. In this study we demonstrate that leptin activates and induces significantly greater amount of IL-6, TNF-α, and IL-10 by B cells from aged humans as compared to young controls. This is associated with increased leptin-induced phosphorylation of STAT3 (signal transducer and activator of transcription-3) in B cells from aged humans as compared to young subjects. These data suggest that leptin-induced B cell-derived proinflammatory cytokines may play a role in chronic inflammation associated with human aging. |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 6% |
| Unknown | 32 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 32% |
| Researcher | 6 | 18% |
| Student > Master | 4 | 12% |
| Student > Bachelor | 3 | 9% |
| Student > Postgraduate | 2 | 6% |
| Other | 1 | 3% |
| Unknown | 7 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 10 | 29% |
| Agricultural and Biological Sciences | 9 | 26% |
| Medicine and Dentistry | 4 | 12% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Unknown | 9 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2013.
All research outputs
#13,380,993
of 22,703,044 outputs
Outputs from Immunity & Ageing
#184
of 369 outputs
Outputs of similar age
#157,071
of 280,514 outputs
Outputs of similar age from Immunity & Ageing
#2
of 3 outputs
Altmetric has tracked 22,703,044 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 369 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.8. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,514 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.