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Mesenchymal stromal cell treatment prevents H9N2 avian influenza virus-induced acute lung injury in mice

Overview of attention for article published in Stem Cell Research & Therapy, October 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

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4 tweeters
facebook
1 Facebook page

Citations

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34 Dimensions

Readers on

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41 Mendeley
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Title
Mesenchymal stromal cell treatment prevents H9N2 avian influenza virus-induced acute lung injury in mice
Published in
Stem Cell Research & Therapy, October 2016
DOI 10.1186/s13287-016-0395-z
Pubmed ID
Authors

Yan Li, Jun Xu, Weiqing Shi, Cheng Chen, Yan Shao, Limei Zhu, Wei Lu, XiaoDong Han

Abstract

The avian influenza virus (AIV) can cross species barriers and expand its host range from birds to mammals, even humans. Avian influenza is characterized by pronounced activation of the proinflammatory cytokine cascade, which perpetuates the inflammatory response, leading to persistent systemic inflammatory response syndrome and pulmonary infection in animals and humans. There are currently no specific treatment strategies for avian influenza. We hypothesized that mesenchymal stromal cells (MSCs) would have beneficial effects in the treatment of H9N2 AIV-induced acute lung injury in mice. Six- to 8-week-old C57BL/6 mice were infected intranasally with 1 × 10(4) MID50 of A/HONG KONG/2108/2003 [H9N2 (HK)] H9N2 virus to induce acute lung injury. After 30 min, syngeneic MSCs were delivered through the caudal vein. Three days after infection, we measured the survival rate, lung weight, arterial blood gas, and cytokines in both bronchoalveolar lavage fluid (BALF) and serum, and assessed pathological changes to the lungs. MSC administration significantly palliated H9N2 AIV-induced pulmonary inflammation by reducing chemokines and proinflammatory cytokines levels, as well as reducing inflammatory cell recruit into the lungs. Thus, H9N2 AIV-induced lung injury was markedly alleviated in mice treated with MSCs. Lung histopathology and arterial blood gas analysis were improved in mice with H9N2 AIV-induced lung injury following MSC treatment. MSC treatment significantly reduces H9N2 AIV-induced acute lung injury in mice and is associated with reduced pulmonary inflammation. These results indicate a potential role for MSC therapy in the treatment of clinical avian influenza.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 17%
Student > Ph. D. Student 4 10%
Student > Master 4 10%
Student > Bachelor 4 10%
Professor 3 7%
Other 7 17%
Unknown 12 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 22%
Medicine and Dentistry 7 17%
Agricultural and Biological Sciences 3 7%
Nursing and Health Professions 1 2%
Unspecified 1 2%
Other 2 5%
Unknown 18 44%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2017.
All research outputs
#6,550,748
of 12,140,050 outputs
Outputs from Stem Cell Research & Therapy
#425
of 1,004 outputs
Outputs of similar age
#112,272
of 257,273 outputs
Outputs of similar age from Stem Cell Research & Therapy
#10
of 30 outputs
Altmetric has tracked 12,140,050 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,004 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,273 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.