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Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance

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Cover of 'Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction to microRNAs: Biogenesis, Action, Relevance of Tissue microRNAs in Disease Pathogenesis, Diagnosis and Therapy-The Concept of Circulating microRNAs.
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    Chapter 2 Extracellular microRNAs in Membrane Vesicles and Non-vesicular Carriers
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    Chapter 3 Technical Aspects Related to the Analysis of Circulating microRNAs.
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    Chapter 4 Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors.
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    Chapter 5 Circulating microRNA as Biomarkers in Hematological Malignancies.
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    Chapter 6 Circulating microRNAs as Biomarkers in Cardiovascular Diseases.
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    Chapter 7 Circulating microRNAs in Neurodegenerative Diseases.
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    Chapter 8 Circulating Extracellular microRNA in Systemic Autoimmunity.
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    Chapter 9 Circulating microRNAs in Inflammatory Bowel Diseases.
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    Chapter 10 Circulating microRNAs in Diabetes Progression: Discovery, Validation, and Research Translation.
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    Chapter 11 Diagnostic Relevance of microRNAs in Other Body Fluids Including Urine, Feces, and Saliva.
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    Chapter 12 Circulating microRNAs as Hormones: Intercellular and Inter-organ Conveyors of Epigenetic Information?
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    Chapter 13 Are Circulating microRNAs Involved in Tumor Surveillance?
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    Chapter 14 Hypothetic Interindividual and Interspecies Relevance of microRNAs Released in Body Fluids.
Attention for Chapter 13: Are Circulating microRNAs Involved in Tumor Surveillance?
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Chapter title
Are Circulating microRNAs Involved in Tumor Surveillance?
Chapter number 13
Book title
Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance
Published in
EXS, January 2015
DOI 10.1007/978-3-0348-0955-9_13
Pubmed ID
26608209
Book ISBNs
978-3-03-480953-5, 978-3-03-480955-9
Authors

Igaz, Ivan, Igaz, Peter, Ivan Igaz, Peter Igaz

Abstract

By studying literature data and having performed an in silico analysis, the circulating microRNA expression profiles of healthy individuals appear to show an abundance of microRNAs with predominant tumor suppressor activity. We hypothesize that circulating tumor suppressor microRNAs might constitute a sort of continuous tumor surveillance, whereby circulating microRNAs delivering gene expression modulating epigenetic information might halt cell transformation and tumorigenesis. This mechanism might complement the well-known cancer immune surveillance. A further hypothesis is also discussed, supposing that the tissue specific action of microRNAs might represent a putative defense mechanism against the potential tumor-promoting actions of secreted miRNA.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 100%
Readers by discipline Count As %
Agricultural and Biological Sciences 1 50%
Medicine and Dentistry 1 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2015.
All research outputs
#18,431,664
of 22,834,308 outputs
Outputs from EXS
#72
of 94 outputs
Outputs of similar age
#255,931
of 353,194 outputs
Outputs of similar age from EXS
#7
of 14 outputs
Altmetric has tracked 22,834,308 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 94 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.

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