Chapter title |
Circulating microRNAs as Hormones: Intercellular and Inter-organ Conveyors of Epigenetic Information?
|
---|---|
Chapter number | 12 |
Book title |
Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance
|
Published in |
EXS, January 2015
|
DOI | 10.1007/978-3-0348-0955-9_12 |
Pubmed ID | |
Book ISBNs |
978-3-03-480953-5, 978-3-03-480955-9
|
Authors |
Yoshioka, Yusuke, Katsuda, Takeshi, Ochiya, Takahiro, Yusuke Yoshioka, Takeshi Katsuda, Takahiro Ochiya |
Abstract |
The discovery of microRNAs (miRNAs) has created a paradigm shift not only in the traditional central dogma of molecular biology but also in the research of a variety of human diseases. Fourteen years after the discovery of miRNAs, there was another revolutionary finding: cells can shuttle miRNAs between each other via small lipid bilayer vesicles called exosomes. This exosome-mediated horizontal transfer of genetically encoded messages is now recognized as a means of intercellular communication. This chapter reviews the concept that miRNAs can function as hormones conveying epigenetic information. |
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