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Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance

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Cover of 'Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction to microRNAs: Biogenesis, Action, Relevance of Tissue microRNAs in Disease Pathogenesis, Diagnosis and Therapy-The Concept of Circulating microRNAs.
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    Chapter 2 Extracellular microRNAs in Membrane Vesicles and Non-vesicular Carriers
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    Chapter 3 Technical Aspects Related to the Analysis of Circulating microRNAs.
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    Chapter 4 Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors.
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    Chapter 5 Circulating microRNA as Biomarkers in Hematological Malignancies.
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    Chapter 6 Circulating microRNAs as Biomarkers in Cardiovascular Diseases.
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    Chapter 7 Circulating microRNAs in Neurodegenerative Diseases.
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    Chapter 8 Circulating Extracellular microRNA in Systemic Autoimmunity.
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    Chapter 9 Circulating microRNAs in Inflammatory Bowel Diseases.
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    Chapter 10 Circulating microRNAs in Diabetes Progression: Discovery, Validation, and Research Translation.
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    Chapter 11 Diagnostic Relevance of microRNAs in Other Body Fluids Including Urine, Feces, and Saliva.
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    Chapter 12 Circulating microRNAs as Hormones: Intercellular and Inter-organ Conveyors of Epigenetic Information?
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    Chapter 13 Are Circulating microRNAs Involved in Tumor Surveillance?
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    Chapter 14 Hypothetic Interindividual and Interspecies Relevance of microRNAs Released in Body Fluids.
Attention for Chapter 4: Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors.
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Chapter title
Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors.
Chapter number 4
Book title
Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance
Published in
EXS, January 2015
DOI 10.1007/978-3-0348-0955-9_4
Pubmed ID
Book ISBNs
978-3-03-480953-5, 978-3-03-480955-9
Authors

Vychytilova-Faltejskova, Petra, Slaby, Ondrej, Petra Vychytilova-Faltejskova, Ondrej Slaby

Abstract

One of the major challenges in cancer research is the identification of stable biomarkers that could be routinely measured in easily accessible samples. Human blood and other body fluids represent rich sources for the identification of novel biomarkers. It is apparent that the availability of these biomarkers would improve an early detection of asymptomatic disease and the clinical management of cancer. MicroRNAs have been described to be present in various types of body fluids including cell-free serum and plasma. These days, the involvement of microRNAs in molecular pathology of cancer is well established. Moreover, it seems that these molecules could be optimal noninvasive biomarkers owing to their high stability under storage and handling conditions and high sensitivity and specificity in various diseases. To date, more than 100 circulating microRNAs with the potential to serve as novel diagnostic, prognostic, or predictive biomarkers for different types of cancers have been identified, and this number is still increasing. However, there are major discrepancies in the findings by different research groups, and few commonly altered microRNAs have been reported in these studies. Further studies on large cohorts using uniform methodology are warranted to establish the clinical applicability of circulating microRNAs for solid tumors. Here, we summarize the tumor-specific profiles of blood-borne microRNAs and discuss their potential utility for personalized medicine of solid tumors.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 25%
Researcher 2 25%
Lecturer 1 13%
Student > Postgraduate 1 13%
Unknown 2 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 25%
Pharmacology, Toxicology and Pharmaceutical Science 1 13%
Agricultural and Biological Sciences 1 13%
Medicine and Dentistry 1 13%
Unknown 3 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2015.
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#5,644,824
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Outputs of similar age from EXS
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