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Integrated acoustic immunoaffinity-capture (IAI) platform for detection of PSA from whole blood samples

Overview of attention for article published in Lab on a Chip - Miniaturisation for Chemistry & Biology, January 2013
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Title
Integrated acoustic immunoaffinity-capture (IAI) platform for detection of PSA from whole blood samples
Published in
Lab on a Chip - Miniaturisation for Chemistry & Biology, January 2013
DOI 10.1039/c3lc41269e
Pubmed ID
23515524
Authors

A. Ahmad Tajudin, K. Petersson, A. Lenshof, A.-M. Swärd-Nilsson, L. Åberg, G. Marko-Varga, J. Malm, H. Lilja, T. Laurell

Abstract

On-chip detection of low abundant protein biomarkers is of interest to enable point-of-care diagnostics. Using a simple form of integration, we have realized an integrated microfluidic platform for the detection of prostate specific antigen (PSA), directly in anti-coagulated whole blood. We combine acoustophoresis-based separation of plasma from undiluted whole blood with a miniaturized immunoassay system in a polymer manifold, demonstrating improved assay speed on our Integrated Acoustic Immunoaffinity-capture (IAI) platform. The IAI platform separates plasma from undiluted whole blood by means of acoustophoresis and provides cell free plasma of clinical quality at a rate of 10 uL/min for an online immunoaffinity-capture of PSA on a porous silicon antibody microarray. The whole blood input (hematocrit 38-40%) rate was 50 μl min(-1) giving a plasma volume fraction yield of ≈33%. PSA was immunoaffinity-captured directly from spiked female whole blood samples at clinically significant levels of 1.7-100 ng ml(-1) within 15 min and was subsequently detected via fluorescence readout, showing a linear response over the entire range with a coefficient of variation of 13%.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
Unknown 42 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 37%
Student > Master 7 16%
Researcher 6 14%
Student > Bachelor 3 7%
Professor 3 7%
Other 5 12%
Unknown 3 7%
Readers by discipline Count As %
Engineering 17 40%
Chemical Engineering 4 9%
Chemistry 4 9%
Agricultural and Biological Sciences 3 7%
Medicine and Dentistry 3 7%
Other 7 16%
Unknown 5 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2013.
All research outputs
#4,607,782
of 6,230,503 outputs
Outputs from Lab on a Chip - Miniaturisation for Chemistry & Biology
#1,134
of 1,949 outputs
Outputs of similar age
#66,009
of 98,527 outputs
Outputs of similar age from Lab on a Chip - Miniaturisation for Chemistry & Biology
#7
of 13 outputs
Altmetric has tracked 6,230,503 research outputs across all sources so far. This one is in the 15th percentile – i.e., 15% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,949 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 98,527 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.

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