Chapter title |
ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities.
|
---|---|
Chapter number | 3 |
Book title |
Cancer Gene Networks
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6539-7_3 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6537-3, 978-1-4939-6539-7
|
Authors |
Ximena Leighton, Ofer Eidelman, Catherine Jozwik, Harvey B. Pollard, Meera Srivastava |
Editors |
Usha Kasid, Robert Clarke |
Abstract |
Chromosomal abnormalities, including homozygous deletions and loss of heterozygosity at 10q, are commonly observed in most human tumors, including prostate, breast, and kidney cancers. The ANXA7-GTPase is a tumor suppressor, which is frequently inactivated by genomic alterations at 10q21. In the last few years, considerable amounts of data have accumulated describing inactivation of ANXA7-GTPase in a variety of human malignancies and demonstrating the tumor suppressor potential of ANXA7-GTPase. ANXA7-GTPase contains a calcium binding domain that classifies it as a member of the annexin family. The cancer-specific expression of ANXA7-GTPase, coupled with its importance in regulating cell death, cell motility, and invasion, makes it a useful diagnostic marker of cancer and a potential target for cancer treatment. Recently, emerging evidence suggests that ANXA7-GTPase is a critical factor associated with the metastatic state of several cancers and can be used as a risk biomarker for HER2 negative breast cancer patients. Cross talk between ANXA7, PTEN, and EGFR leads to constitutive activation of PI3K-AKT signaling, a central pathway of tumor cell survival and proliferation. This review focuses on the recent progress in understanding the tumor suppressor functions of ANXA7-GTPase emphasizing the role of this gene in Ca(2+) metabolism, and exploring opportunities for function as an example of a calcium binding GTPase acting as a tumor suppressor and opportunities for ANXA7-GTPase gene cancer therapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 45% |
Student > Bachelor | 2 | 18% |
Student > Doctoral Student | 1 | 9% |
Unspecified | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Other | 1 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 45% |
Unspecified | 1 | 9% |
Agricultural and Biological Sciences | 1 | 9% |
Biochemistry, Genetics and Molecular Biology | 1 | 9% |
Immunology and Microbiology | 1 | 9% |
Other | 1 | 9% |
Unknown | 1 | 9% |