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Cancer Gene Networks

Overview of attention for book
Cover of 'Cancer Gene Networks'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Introduction: Cancer Gene Networks.
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    Chapter 2 Emerging Methods in Chemoproteomics with Relevance to Drug Discovery.
  4. Altmetric Badge
    Chapter 3 ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities.
  5. Altmetric Badge
    Chapter 4 Experimental and Study Design Considerations for Uncovering Oncometabolites.
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    Chapter 5 Targeting Deubiquitinating Enzymes and Autophagy in Cancer.
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    Chapter 6 Quantitative Clinical Imaging Methods for Monitoring Intratumoral Evolution.
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    Chapter 7 Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression.
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    Chapter 8 Network-Oriented Approaches to Anticancer Drug Response.
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    Chapter 9 CRISPR/Cas-Mediated Knockin in Human Pluripotent Stem Cells.
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    Chapter 10 Complete Transcriptome RNA-Seq.
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    Chapter 11 Computational Methods and Correlation of Exon-skipping Events with Splicing, Transcription, and Epigenetic Factors.
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    Chapter 12 Tissue Engineering Platforms to Replicate the Tumor Microenvironment of Multiple Myeloma.
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    Chapter 13 microRNA Target Prediction.
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    Chapter 14 Evaluating the Delivery of Proteins to the Cytosol of Mammalian Cells.
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    Chapter 15 Validation of Biomarker Proteins Using Reverse Capture Protein Microarrays.
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    Chapter 16 Chemical Synthesis of Activity-Based Diubiquitin Probes.
  18. Altmetric Badge
    Chapter 17 Profiling the Dual Enzymatic Activities of the Serine/Threonine Kinase IRE1α.
Attention for Chapter 7: Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression.
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Chapter title
Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression.
Chapter number 7
Book title
Cancer Gene Networks
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6539-7_7
Pubmed ID
Book ISBNs
978-1-4939-6537-3, 978-1-4939-6539-7
Authors

Timothy F. Day, Rajshree R. Mewani, Joshua Starr, Xin Li, Debyani Chakravarty, Habtom Ressom, Xiaojun Zou, Ofer Eidelman, Harvey B. Pollard, Meera Srivastava, Usha N. Kasid

Editors

Usha Kasid, Robert Clarke

Abstract

Tumor necrosis factor-α-inducible protein 8 (TNFAIP8) is the first discovered oncogenic and an anti-apoptotic member of a conserved TNFAIP8 or TIPE family of proteins. TNFAIP8 mRNA is induced by NF-kB, and overexpression of TNFAIP8 has been correlated with poor prognosis in many cancers. Downregulation of TNFAIP8 expression has been associated with decreased pulmonary colonization of human tumor cells, and enhanced sensitivities of tumor xenografts to radiation and docetaxel. Here we have investigated the effects of depletion of TNFAIP8 on the mRNA, microRNA and protein expression profiles in prostate and breast cancers and melanoma. Depending on the tumor cell type, knockdown of TNFAIP8 was found to be associated with increased mRNA expression of several antiproliferative and apoptotic genes (e.g., IL-24, FAT3, LPHN2, EPHA3) and fatty acid oxidation gene ACADL, and decreased mRNA levels of oncogenes (e.g., NFAT5, MALAT1, MET, FOXA1, KRAS, S100P, OSTF1) and glutamate transporter gene SLC1A1. TNFAIP8 knockdown cells also exhibited decreased expression of multiple onco-proteins (e.g., PIK3CA, SRC, EGFR, IL5, ABL1, GAP43), and increased expression of the orphan nuclear receptor NR4A1 and alpha 1 adaptin subunit of the adaptor-related protein complex 2 AP2 critical to clathrin-mediated endocytosis. TNFAIP8-centric molecules were found to be predominately implicated in the hypoxia-inducible factor-1α (HIF-1α) signaling pathway, and cancer and development signaling networks. Thus TNFAIP8 seems to regulate the cell survival and cancer progression processes in a multifaceted manner. Future validation of the molecules identified in this study is likely to lead to new subset of molecules and functional determinants of cancer cell survival and progression.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 39%
Student > Bachelor 3 17%
Researcher 2 11%
Student > Ph. D. Student 2 11%
Other 1 6%
Other 2 11%
Unknown 1 6%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 33%
Agricultural and Biological Sciences 3 17%
Medicine and Dentistry 3 17%
Computer Science 1 6%
Neuroscience 1 6%
Other 1 6%
Unknown 3 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2017.
All research outputs
#8,994,580
of 11,251,036 outputs
Outputs from Methods in molecular biology
#3,844
of 7,626 outputs
Outputs of similar age
#174,591
of 251,415 outputs
Outputs of similar age from Methods in molecular biology
#23
of 55 outputs
Altmetric has tracked 11,251,036 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,626 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
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We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.