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Cancer Gene Networks

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Cover of 'Cancer Gene Networks'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction: Cancer Gene Networks.
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    Chapter 2 Emerging Methods in Chemoproteomics with Relevance to Drug Discovery.
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    Chapter 3 ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities.
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    Chapter 4 Experimental and Study Design Considerations for Uncovering Oncometabolites.
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    Chapter 5 Targeting Deubiquitinating Enzymes and Autophagy in Cancer.
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    Chapter 6 Quantitative Clinical Imaging Methods for Monitoring Intratumoral Evolution.
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    Chapter 7 Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression.
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    Chapter 8 Network-Oriented Approaches to Anticancer Drug Response.
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    Chapter 9 CRISPR/Cas-Mediated Knockin in Human Pluripotent Stem Cells.
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    Chapter 10 Complete Transcriptome RNA-Seq.
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    Chapter 11 Computational Methods and Correlation of Exon-skipping Events with Splicing, Transcription, and Epigenetic Factors.
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    Chapter 12 Tissue Engineering Platforms to Replicate the Tumor Microenvironment of Multiple Myeloma.
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    Chapter 13 microRNA Target Prediction.
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    Chapter 14 Evaluating the Delivery of Proteins to the Cytosol of Mammalian Cells.
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    Chapter 15 Validation of Biomarker Proteins Using Reverse Capture Protein Microarrays.
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    Chapter 16 Chemical Synthesis of Activity-Based Diubiquitin Probes.
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    Chapter 17 Profiling the Dual Enzymatic Activities of the Serine/Threonine Kinase IRE1α.
Attention for Chapter 12: Tissue Engineering Platforms to Replicate the Tumor Microenvironment of Multiple Myeloma.
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Chapter title
Tissue Engineering Platforms to Replicate the Tumor Microenvironment of Multiple Myeloma.
Chapter number 12
Book title
Cancer Gene Networks
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6539-7_12
Pubmed ID
Book ISBNs
978-1-4939-6537-3, 978-1-4939-6539-7
Authors

Wenting Zhang, Woo Y. Lee, Jenny Zilberberg

Editors

Usha Kasid, Robert Clarke

Abstract

We described here the manufacturing and implementation of two prototype perfusion culture devices designed primarily for the cultivation of difficult-to-preserve primary patient-derived multiple myeloma cells (MMC). The first device consists of an osteoblast (OSB)-derived 3D tissue scaffold constructed in a perfused microfluidic environment. The second platform is a 96-well plate-modified perfusion culture device that can be utilized to reconstruct several tissue and tumor microenvironments utilizing both primary human and murine cells. This culture device was designed and fabricated specifically to: (1) enable the preservation of primary MMC for downstream use in biological studies and chemosensitivity analyses and, (2) provide a high-throughput format that is compatible with plate readers specifically seeing that this system is built on an industry standard 96-well tissue culture plate.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 40%
Researcher 2 20%
Other 1 10%
Student > Master 1 10%
Unknown 2 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 20%
Materials Science 2 20%
Medicine and Dentistry 2 20%
Psychology 1 10%
Neuroscience 1 10%
Other 0 0%
Unknown 2 20%