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Attention Score in Context
| Chapter title |
Profiling the Dual Enzymatic Activities of the Serine/Threonine Kinase IRE1α.
|
|---|---|
| Chapter number | 17 |
| Book title |
Cancer Gene Networks
|
| Published in |
Methods in molecular biology, January 2017
|
| DOI | 10.1007/978-1-4939-6539-7_17 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6537-3, 978-1-4939-6539-7
|
| Authors |
Hannah C. Feldman, Dustin J. Maly |
| Editors |
Usha Kasid, Robert Clarke |
| Abstract |
There is an allosteric relationship between the kinase and RNase domains of the ER stress sensor IRE1α. This relationship has been exploited to develop ATP-competitive inhibitors that are able to divergently modulate the RNase activity of IRE1α through its kinase domain. Here, we describe a series of biochemical methods for profiling the dual enzymatic activities of IRE1α. These methods can be used to ascertain how ATP-competitive inhibitors affect the kinase activity of IRE1α and for determining whether these ligands allosterically activate or inactivate RNase activity. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2018.
All research outputs
#20,351,881
of 22,899,952 outputs
Outputs from Methods in molecular biology
#9,922
of 13,134 outputs
Outputs of similar age
#355,310
of 420,444 outputs
Outputs of similar age from Methods in molecular biology
#845
of 1,074 outputs
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So far Altmetric has tracked 13,134 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1,074 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.