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Antibody recognition of aberrant glycosylation on the surface of cancer cells

Overview of attention for article published in Current Opinion in Structural Biology, June 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

twitter
20 tweeters

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
61 Mendeley
citeulike
1 CiteULike
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Title
Antibody recognition of aberrant glycosylation on the surface of cancer cells
Published in
Current Opinion in Structural Biology, June 2017
DOI 10.1016/j.sbi.2016.10.009
Pubmed ID
Authors

Caroline Soliman, Elizabeth Yuriev, Paul A Ramsland

Abstract

Carbohydrate-binding antibodies and carbohydrate-based vaccines are being actively pursued as targeted immunotherapies for a broad range of cancers. Recognition of tumor-associated carbohydrates (glycans) by antibodies is predominantly towards terminal epitopes on glycoproteins and glycolipids on the surface of cancer cells. Crystallography along with complementary experimental and computational methods have been extensively used to dissect antibody recognition of glycan epitopes commonly found in cancer. We provide an overview of the structural biology of antibody recognition of tumor-associated glycans and propose potential rearrangements of these targets in the membrane that could dictate the complex biological activities of these antibodies against cancer cells.

Twitter Demographics

The data shown below were collected from the profiles of 20 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 3%
Netherlands 2 3%
Unknown 57 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 31%
Student > Bachelor 10 16%
Student > Master 10 16%
Unspecified 7 11%
Researcher 5 8%
Other 10 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 30%
Biochemistry, Genetics and Molecular Biology 11 18%
Unspecified 8 13%
Chemistry 8 13%
Immunology and Microbiology 4 7%
Other 12 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2017.
All research outputs
#1,289,121
of 12,502,636 outputs
Outputs from Current Opinion in Structural Biology
#66
of 1,248 outputs
Outputs of similar age
#46,072
of 281,983 outputs
Outputs of similar age from Current Opinion in Structural Biology
#3
of 37 outputs
Altmetric has tracked 12,502,636 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,248 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,983 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.