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IgD attenuates the IgM-induced anergy response in transitional and mature B cells

Overview of attention for article published in Nature Communications, November 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Citations

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94 Mendeley
Title
IgD attenuates the IgM-induced anergy response in transitional and mature B cells
Published in
Nature Communications, November 2016
DOI 10.1038/ncomms13381
Pubmed ID
Authors

Zahra Sabouri, Samuel Perotti, Emily Spierings, Peter Humburg, Mehmet Yabas, Hannes Bergmann, Keisuke Horikawa, Carla Roots, Samantha Lambe, Clara Young, T. Dan Andrews, Matthew Field, Anselm Enders, Joanne H. Reed, Christopher C. Goodnow

Abstract

Self-tolerance by clonal anergy of B cells is marked by an increase in IgD and decrease in IgM antigen receptor surface expression, yet the function of IgD on anergic cells is obscure. Here we define the RNA landscape of the in vivo anergy response, comprising 220 induced sequences including a core set of 97. Failure to co-express IgD with IgM decreases overall expression of receptors for self-antigen, but paradoxically increases the core anergy response, exemplified by increased Sdc1 encoding the cell surface marker syndecan-1. IgD expressed on its own is nevertheless competent to induce calcium signalling and the core anergy mRNA response. Syndecan-1 induction correlates with reduction of surface IgM and is exaggerated without surface IgD in many transitional and mature B cells. These results show that IgD attenuates the response to self-antigen in anergic cells and promotes their accumulation. In this way, IgD minimizes tolerance-induced holes in the pre-immune antibody repertoire.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Netherlands 1 1%
Switzerland 1 1%
Unknown 91 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 23 24%
Student > Ph. D. Student 22 23%
Student > Bachelor 17 18%
Student > Master 7 7%
Student > Postgraduate 3 3%
Other 8 9%
Unknown 14 15%
Readers by discipline Count As %
Immunology and Microbiology 26 28%
Agricultural and Biological Sciences 21 22%
Biochemistry, Genetics and Molecular Biology 16 17%
Medicine and Dentistry 10 11%
Psychology 1 1%
Other 5 5%
Unknown 15 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 69. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2018.
All research outputs
#285,066
of 14,565,263 outputs
Outputs from Nature Communications
#5,212
of 27,459 outputs
Outputs of similar age
#10,966
of 288,871 outputs
Outputs of similar age from Nature Communications
#734
of 2,998 outputs
Altmetric has tracked 14,565,263 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 27,459 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 48.2. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,871 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 2,998 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.