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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting
|
|---|---|
| Published in |
Science, November 2016
|
| DOI | 10.1126/science.aag1322 |
| Pubmed ID | |
| Authors |
Katelyn M Gostic, Monique Ambrose, Michael Worobey, James O Lloyd-Smith |
| Abstract |
Two zoonotic influenza A viruses (IAV) of global concern, H5N1 and H7N9, exhibit unexplained differences in age distribution of human cases. Using data from all known human cases of these viruses, we show that an individual's first IAV infection confers lifelong protection against severe disease from novel hemagglutinin (HA) subtypes in the same phylogenetic group. Statistical modeling shows that protective HA imprinting is the crucial explanatory factor, and it provides 75% protection against severe infection and 80% protection against death for both H5N1 and H7N9. Our results enable us to predict age distributions of severe disease for future pandemics and demonstrate that a novel strain's pandemic potential increases yearly when a group-mismatched HA subtype dominates seasonal influenza circulation. These findings open new frontiers for rational pandemic risk assessment. |
X Demographics
The data shown below were collected from the profiles of 192 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 40 | 21% |
| United Kingdom | 20 | 10% |
| Germany | 10 | 5% |
| Canada | 4 | 2% |
| France | 4 | 2% |
| Spain | 4 | 2% |
| Australia | 3 | 2% |
| Denmark | 2 | 1% |
| Italy | 2 | 1% |
| Other | 13 | 7% |
| Unknown | 90 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 136 | 71% |
| Scientists | 38 | 20% |
| Practitioners (doctors, other healthcare professionals) | 12 | 6% |
| Science communicators (journalists, bloggers, editors) | 6 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 354 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | <1% |
| Sweden | 1 | <1% |
| Vietnam | 1 | <1% |
| Belgium | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 347 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 84 | 24% |
| Student > Ph. D. Student | 81 | 23% |
| Student > Bachelor | 38 | 11% |
| Student > Master | 28 | 8% |
| Professor | 15 | 4% |
| Other | 50 | 14% |
| Unknown | 58 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 77 | 22% |
| Immunology and Microbiology | 61 | 17% |
| Biochemistry, Genetics and Molecular Biology | 44 | 12% |
| Medicine and Dentistry | 30 | 8% |
| Engineering | 9 | 3% |
| Other | 63 | 18% |
| Unknown | 70 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1561. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2023.
All research outputs
#7,406
of 25,722,279 outputs
Outputs from Science
#401
of 83,260 outputs
Outputs of similar age
#96
of 317,724 outputs
Outputs of similar age from Science
#4
of 1,141 outputs
Altmetric has tracked 25,722,279 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,260 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,724 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,141 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.