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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Overview of attention for article published in Nature Genetics, April 2007
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

blogs
1 blog
policy
1 policy source
twitter
1 tweeter
patent
4 patents
wikipedia
1 Wikipedia page
f1000
1 research highlight platform

Citations

dimensions_citation
1315 Dimensions

Readers on

mendeley
504 Mendeley
citeulike
4 CiteULike
connotea
5 Connotea
Title
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
Published in
Nature Genetics, April 2007
DOI 10.1038/ng2032
Pubmed ID
Authors

John D Rioux, Ramnik J Xavier, Kent D Taylor, Mark S Silverberg, Philippe Goyette, Alan Huett, Todd Green, Petric Kuballa, M Michael Barmada, Lisa Wu Datta, Yin Yao Shugart, Anne M Griffiths, Stephan R Targan, Andrew F Ippoliti, Edmond-Jean Bernard, Ling Mei, Dan L Nicolae, Miguel Regueiro, L Philip Schumm, A Hillary Steinhart, Jerome I Rotter, Richard H Duerr, Judy H Cho, Mark J Daly, Steven R Brant

Abstract

We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of association to Crohn disease. Specifically, in addition to the previously established CARD15 and IL23R associations, we identified strong and significantly replicated associations (combined P < 10(-10)) with an intergenic region on 10q21.1 and a coding variant in ATG16L1, the latter of which was also recently reported by another group. We also report strong associations with independent replication to variation in the genomic regions encoding PHOX2B, NCF4 and a predicted gene on 16q24.1 (FAM92B). Finally, we demonstrate that ATG16L1 is expressed in intestinal epithelial cell lines and that functional knockdown of this gene abrogates autophagy of Salmonella typhimurium. Together, these findings suggest that autophagy and host cell responses to intracellular microbes are involved in the pathogenesis of Crohn disease.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 504 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 12 2%
United Kingdom 7 1%
Germany 5 <1%
Brazil 3 <1%
Austria 1 <1%
Sweden 1 <1%
Australia 1 <1%
Iran, Islamic Republic of 1 <1%
Canada 1 <1%
Other 4 <1%
Unknown 468 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 117 23%
Student > Ph. D. Student 117 23%
Student > Master 61 12%
Professor > Associate Professor 41 8%
Student > Bachelor 40 8%
Other 128 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 215 43%
Medicine and Dentistry 116 23%
Biochemistry, Genetics and Molecular Biology 52 10%
Unspecified 43 9%
Immunology and Microbiology 32 6%
Other 46 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2019.
All research outputs
#900,011
of 13,865,625 outputs
Outputs from Nature Genetics
#1,698
of 6,247 outputs
Outputs of similar age
#868,318
of 13,152,411 outputs
Outputs of similar age from Nature Genetics
#1,697
of 6,246 outputs
Altmetric has tracked 13,865,625 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,247 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.5. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 13,152,411 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 6,246 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.