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Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report

Overview of attention for article published in Basic and Clinical Andrology, November 2016
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Title
Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report
Published in
Basic and Clinical Andrology, November 2016
DOI 10.1186/s12610-016-0041-8
Pubmed ID
Authors

J. Prasivoravong, A-L. Barbotin, A. Derveaux, C. Leroy, X. Leroy, P. Puech, V. Mitchell, F. Marcelli, J-M. Rigot

Abstract

Secreting interstitial cell (Leydig cell) tumors are rare. In adults, the clinical picture and steroid levels are variable. This paper presents a case of left testicular tumor, showing azoospermia with normal serum level of total testosterone, collapsed FSH and LH, and high delta4 androstenedione. Histopathological investigation revealed a Leydig cell tumor. TESE allowed spermatozoa extraction and freezing. Testicular histology found hypospermatogenesis and germ-cell aplasia with interstitial fibrosis. Surgical resection of the tumor resulted in normalization of gonadotropins and fall in serum delta4 androstenedione to subnormal levels in the postoperative period confirming that the tumor was secreting delta4 androstenedione. It was hypothesized that high delta4 androstenedione resulted in intra tumoral 17 β-HSD overtaken by delta4 androstenedione or that 17 β-HSD activity in the tumor was different from that of normal Leydig cells. Three months after surgery sperm analysis found a complete recovery of spermatogenesis. A spontaneous pregnancy occurred 3 months after surgery and a girl was born. In this case, the diagnosis of testicular Leydig cell tumor secreting delta4 androstenedione was made in a context of azoospermia.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 40%
Other 1 20%
Student > Postgraduate 1 20%
Student > Bachelor 1 20%
Readers by discipline Count As %
Medicine and Dentistry 5 100%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2016.
All research outputs
#7,479,611
of 8,624,496 outputs
Outputs from Basic and Clinical Andrology
#33
of 39 outputs
Outputs of similar age
#197,081
of 241,560 outputs
Outputs of similar age from Basic and Clinical Andrology
#4
of 4 outputs
Altmetric has tracked 8,624,496 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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