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Chapter title |
Selecting Optimal Peptides for Targeted Proteomic Experiments in Human Plasma Using In Vitro Synthesized Proteins as Analytical Standards.
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---|---|
Chapter number | 12 |
Book title |
Quantitative Proteomics by Mass Spectrometry
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Published in |
Methods in molecular biology, January 2016
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DOI | 10.1007/978-1-4939-3524-6_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3522-2, 978-1-4939-3524-6
|
Authors |
James G. Bollinger, Andrew B. Stergachis, Richard S. Johnson, Jarrett D. Egertson, Michael J. MacCoss |
Editors |
Salvatore Sechi |
Abstract |
In targeted proteomics, the development of robust methodologies is dependent upon the selection of a set of optimal peptides for each protein-of-interest. Unfortunately, predicting which peptides and respective product ion transitions provide the greatest signal-to-noise ratio in a particular assay matrix is complicated. Using in vitro synthesized proteins as analytical standards, we report here an empirically driven method for the selection of said peptides in a human plasma assay matrix. |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 24% |
Student > Ph. D. Student | 6 | 21% |
Student > Bachelor | 2 | 7% |
Student > Master | 2 | 7% |
Professor > Associate Professor | 2 | 7% |
Other | 2 | 7% |
Unknown | 8 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 31% |
Neuroscience | 2 | 7% |
Engineering | 2 | 7% |
Computer Science | 2 | 7% |
Chemistry | 2 | 7% |
Other | 2 | 7% |
Unknown | 10 | 34% |