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Quantitative Spatial Profiling of Immune Populations in Pancreatic Ductal Adenocarcinoma Reveals Tumor Microenvironment Heterogeneity and Prognostic Biomarkers

Overview of attention for article published in Cancer Research, September 2022
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#36 of 17,812)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
47 news outlets
blogs
1 blog
twitter
40 tweeters

Readers on

mendeley
8 Mendeley
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Title
Quantitative Spatial Profiling of Immune Populations in Pancreatic Ductal Adenocarcinoma Reveals Tumor Microenvironment Heterogeneity and Prognostic Biomarkers
Published in
Cancer Research, September 2022
DOI 10.1158/0008-5472.can-22-1190
Pubmed ID
Authors

Haoyang Mi, Shamilene Sivagnanam, Courtney B. Betts, Shannon M. Liudahl, Elizabeth M. Jaffee, Lisa M. Coussens, Aleksander S. Popel

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with poor 5-year survival rates, necessitating identification of novel therapeutic targets. Elucidating the biology of the tumor immune microenvironment (TiME) can provide vital insights into mechanisms of tumor progression. In this study, we developed a quantitative image processing platform to analyze sequential multiplexed immunohistochemistry data from archival PDAC tissue resection specimens. A 27-plex marker panel was employed to simultaneously phenotype cell populations and their functional states, followed by a computational workflow to interrogate the immune contextures of the TiME in search of potential biomarkers. The PDAC TiME reflected a low-immunogenic ecosystem with both high intratumoral and intertumoral heterogeneity. Spatial analysis revealed that the relative distance between IL-10+ myelomonocytes, PD-1+ CD4+ T cells, and Granzyme B+ CD8+ T cells correlated significantly with survival, from which a spatial proximity signature termed imRS was derived that correlated with PDAC patient survival. Furthermore, spatial enrichment of CD8+ T cells in lymphoid aggregates was also linked to improved survival. Altogether, these findings indicate that the PDAC TiME, generally considered immuno-dormant or immunosuppressive, is a spatially-nuanced ecosystem orchestrated by ordered immune hierarchies. This new understanding of spatial complexity may guide novel treatment strategies for PDAC.

Twitter Demographics

The data shown below were collected from the profiles of 40 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 1 13%
Student > Ph. D. Student 1 13%
Student > Master 1 13%
Researcher 1 13%
Student > Postgraduate 1 13%
Other 0 0%
Unknown 3 38%
Readers by discipline Count As %
Chemical Engineering 1 13%
Biochemistry, Genetics and Molecular Biology 1 13%
Psychology 1 13%
Chemistry 1 13%
Engineering 1 13%
Other 0 0%
Unknown 3 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 373. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2022.
All research outputs
#67,293
of 22,545,203 outputs
Outputs from Cancer Research
#36
of 17,812 outputs
Outputs of similar age
#1,760
of 288,963 outputs
Outputs of similar age from Cancer Research
#1
of 94 outputs
Altmetric has tracked 22,545,203 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,812 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,963 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.