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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Quantitative Spatial Profiling of Immune Populations in Pancreatic Ductal Adenocarcinoma Reveals Tumor Microenvironment Heterogeneity and Prognostic Biomarkers
|
|---|---|
| Published in |
Cancer Research, September 2022
|
| DOI | 10.1158/0008-5472.can-22-1190 |
| Pubmed ID | |
| Authors |
Haoyang Mi, Shamilene Sivagnanam, Courtney B. Betts, Shannon M. Liudahl, Elizabeth M. Jaffee, Lisa M. Coussens, Aleksander S. Popel |
| Abstract |
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with poor 5-year survival rates, necessitating identification of novel therapeutic targets. Elucidating the biology of the tumor immune microenvironment (TiME) can provide vital insights into mechanisms of tumor progression. In this study, we developed a quantitative image processing platform to analyze sequential multiplexed immunohistochemistry data from archival PDAC tissue resection specimens. A 27-plex marker panel was employed to simultaneously phenotype cell populations and their functional states, followed by a computational workflow to interrogate the immune contextures of the TiME in search of potential biomarkers. The PDAC TiME reflected a low-immunogenic ecosystem with both high intratumoral and intertumoral heterogeneity. Spatial analysis revealed that the relative distance between IL-10+ myelomonocytes, PD-1+ CD4+ T cells, and Granzyme B+ CD8+ T cells correlated significantly with survival, from which a spatial proximity signature termed imRS was derived that correlated with PDAC patient survival. Furthermore, spatial enrichment of CD8+ T cells in lymphoid aggregates was also linked to improved survival. Altogether, these findings indicate that the PDAC TiME, generally considered immuno-dormant or immunosuppressive, is a spatially-nuanced ecosystem orchestrated by ordered immune hierarchies. This new understanding of spatial complexity may guide novel treatment strategies for PDAC. |
X Demographics
The data shown below were collected from the profiles of 59 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 20 | 34% |
| United Kingdom | 4 | 7% |
| Germany | 3 | 5% |
| Hong Kong | 2 | 3% |
| India | 2 | 3% |
| Spain | 2 | 3% |
| France | 2 | 3% |
| Brazil | 1 | 2% |
| Norway | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 21 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 35 | 59% |
| Scientists | 18 | 31% |
| Practitioners (doctors, other healthcare professionals) | 5 | 8% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 24% |
| Researcher | 6 | 18% |
| Student > Postgraduate | 3 | 9% |
| Other | 2 | 6% |
| Student > Bachelor | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 9 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 18% |
| Immunology and Microbiology | 4 | 12% |
| Medicine and Dentistry | 4 | 12% |
| Engineering | 2 | 6% |
| Psychology | 2 | 6% |
| Other | 5 | 15% |
| Unknown | 10 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 386. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2023.
All research outputs
#81,464
of 25,775,807 outputs
Outputs from Cancer Research
#48
of 18,888 outputs
Outputs of similar age
#2,407
of 422,282 outputs
Outputs of similar age from Cancer Research
#2
of 104 outputs
Altmetric has tracked 25,775,807 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 18,888 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,282 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.