Title |
Gelsolin activity controls efficient early HIV-1 infection
|
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Published in |
Retrovirology, April 2013
|
DOI | 10.1186/1742-4690-10-39 |
Pubmed ID | |
Authors |
Laura García-Expósito, Serena Ziglio, Jonathan Barroso-González, Laura de Armas-Rillo, María-Soledad Valera, Donato Zipeto, José-David Machado, Agustín Valenzuela-Fernández |
Abstract |
HIV-1 entry into target lymphocytes requires the activity of actin adaptors that stabilize and reorganize cortical F-actin, like moesin and filamin-A. These alterations are necessary for the redistribution of CD4-CXCR4/CCR5 to one pole of the cell, a process that increases the probability of HIV-1 Envelope (Env)-CD4/co-receptor interactions and that generates the tension at the plasma membrane necessary to potentiate fusion pore formation, thereby favouring early HIV-1 infection. However, it remains unclear whether the dynamic processing of F-actin and the amount of cortical actin available during the initial virus-cell contact are required to such events. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
Unknown | 39 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 18% |
Student > Ph. D. Student | 6 | 15% |
Other | 4 | 10% |
Student > Bachelor | 3 | 8% |
Professor | 3 | 8% |
Other | 11 | 28% |
Unknown | 6 | 15% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 9 | 23% |
Immunology and Microbiology | 9 | 23% |
Agricultural and Biological Sciences | 9 | 23% |
Medicine and Dentistry | 4 | 10% |
Philosophy | 1 | 3% |
Other | 2 | 5% |
Unknown | 6 | 15% |