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HIV restriction in quiescent CD4+T cells

Overview of attention for article published in Retrovirology, April 2013
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4 X users

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66 Mendeley
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Title
HIV restriction in quiescent CD4+T cells
Published in
Retrovirology, April 2013
DOI 10.1186/1742-4690-10-37
Pubmed ID
Authors

Jerome A Zack, Sohn G Kim, Dimitrios N Vatakis

Abstract

The restriction of the Human Immunodeficiency Virus (HIV) infection in quiescent CD4⁺ T cells has been an area of active investigation. Early studies have suggested that this T cell subset is refractory to infection by the virus. Subsequently it was demonstrated that quiescent cells could be infected at low levels; nevertheless these observations supported the earlier assertions of debilitating defects in the viral life cycle. This phenomenon raised hopes that identification of the block in quiescent cells could lead to the development of new therapies against HIV. As limiting levels of raw cellular factors such as nucleotides did not account for the block to infection, a number of groups pursued the identification of cellular proteins whose presence or absence may impact the permissiveness of quiescent T cells to HIV infection. A series of studies in the past few years have identified a number of host factors implicated in the block to infection. In this review, we will present the progress made, other avenues of investigation and the potential impact these studies have in the development of more effective therapies against HIV.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
Sweden 1 2%
South Africa 1 2%
Unknown 62 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 29%
Researcher 13 20%
Student > Master 8 12%
Student > Bachelor 5 8%
Student > Doctoral Student 5 8%
Other 6 9%
Unknown 10 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 33%
Immunology and Microbiology 12 18%
Biochemistry, Genetics and Molecular Biology 9 14%
Medicine and Dentistry 7 11%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 7 11%
Unknown 8 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2013.
All research outputs
#15,740,207
of 25,374,647 outputs
Outputs from Retrovirology
#729
of 1,273 outputs
Outputs of similar age
#122,723
of 212,589 outputs
Outputs of similar age from Retrovirology
#14
of 28 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,273 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,589 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.