Title |
Structural mimicry between SLA/LP and Rickettsia surface antigens as a driver of autoimmune hepatitis: insights from an in silico study
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Published in |
Theoretical Biology and Medical Modelling, April 2013
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DOI | 10.1186/1742-4682-10-25 |
Pubmed ID | |
Authors |
Alessandro Paiardini, Stefano Pascarella |
Abstract |
Autoimmune hepatitis (AIH) is a chronic, progressive liver disease, characterized by continuing hepatocellular inflammation and necrosis. A subgroup of AIH patients presents specific autoantibodies to soluble liver antigen/liver-pancreas (SLA/LP) protein, which is regarded as a highly specific diagnostic marker. Autoantigenic SLA/LP peptides are targeted by CD4+ T cells, and restricted by the allele HLA-DRB1*03:01, which confers disease susceptibility in Europeans and Americans. A positively charged residue at position 71 has been indicated as critical for AIH susceptibility in all of the HLA alleles identified to date. Though the exact molecular mechanisms underlying pathogenesis of AIH are not clear, molecular mimicry between SLA/LP and viral/bacterial antigens has been invoked. |
X Demographics
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Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 27% |
Student > Postgraduate | 6 | 18% |
Student > Bachelor | 3 | 9% |
Other | 2 | 6% |
Student > Ph. D. Student | 2 | 6% |
Other | 7 | 21% |
Unknown | 4 | 12% |
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Chemistry | 4 | 12% |
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Immunology and Microbiology | 2 | 6% |
Other | 2 | 6% |
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