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Differences in host breed and diet influence colonization by Campylobacter jejuni and induction of local immune responses in chicken

Overview of attention for article published in Gut Pathogens, November 2016
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  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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Title
Differences in host breed and diet influence colonization by Campylobacter jejuni and induction of local immune responses in chicken
Published in
Gut Pathogens, November 2016
DOI 10.1186/s13099-016-0133-1
Pubmed ID
Authors

Zifeng Han, Thomas Willer, Colin Pielsticker, Lenka Gerzova, Ivan Rychlik, Silke Rautenschlein

Abstract

Chickens are regarded as the main reservoir for human campylobacteriosis. Little is known about the interaction between Campylobacter jejuni (C. jejuni) and chickens. This interaction may be influenced by the stage of maturation of the immune system, developing gut microbiota composition and other factors including breed and diet. Our aim was to investigate the impact of breed, and diet on C. jejuni colonization and host immune responses in chickens. Birds were inoculated with 10(4) colony forming units (CFU) of C. jejuni or diluent at one (Exp. 1) or 22 (Exp. 2) days post hatch. We compared local immune cell subpopulations, cytokine expression levels, and gut microbiota composition between broiler-type (BT) and layer-type (LT) birds fed with either commercial broiler feed (bf) or layer feed (lf). Lower colonization rates were observed in the older age group independent of breed and diet. Independent of breed, birds fed with bf showed higher CFU of C. jejuni compared to lf-fed groups. Campylobacter jejuni-inoculation had a significant effect on lymphocyte numbers and cytokine expression levels in BT birds independent of feeding strategy (p < 0.05). These effects were not detected in LT birds, only LT birds fed with bf showed a significant increase in IL-8-expression at 7 days post C. jejuni inoculation compared to LT-control birds (p < 0.05). Diet influenced gut microbiota composition in a comparable manner between BT and LT birds, but changes in microbiota composition associated with C. jejuni inoculation varied between breeds. Diet and breed influenced C. jejuni colonization, immune responses and microbiota composition to a different extent comparing between LT and BT birds. The mechanisms behind these differences have to be elucidated further. Our results suggest that selection for more resistant breeds in combination with adapted feeding strategies may help to reduce Campylobacter colonization levels in commercial poultry in the future.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Ecuador 1 2%
Unknown 58 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 20%
Researcher 8 13%
Student > Master 8 13%
Student > Bachelor 5 8%
Professor 3 5%
Other 5 8%
Unknown 19 32%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 35%
Veterinary Science and Veterinary Medicine 6 10%
Biochemistry, Genetics and Molecular Biology 4 7%
Immunology and Microbiology 4 7%
Medicine and Dentistry 3 5%
Other 2 3%
Unknown 20 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2016.
All research outputs
#14,217,995
of 22,901,818 outputs
Outputs from Gut Pathogens
#228
of 524 outputs
Outputs of similar age
#177,240
of 312,770 outputs
Outputs of similar age from Gut Pathogens
#6
of 16 outputs
Altmetric has tracked 22,901,818 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 524 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,770 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.