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JAB1/CSN5: a new player in cell cycle control and cancer

Overview of attention for article published in Cell Division, October 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
95 Dimensions

Readers on

mendeley
61 Mendeley
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Title
JAB1/CSN5: a new player in cell cycle control and cancer
Published in
Cell Division, October 2010
DOI 10.1186/1747-1028-5-26
Pubmed ID
Authors

Shackleford TJ, Claret FX, Terry J Shackleford, Francois X Claret

Abstract

c-Jun activation domain-binding protein-1 (Jab1) acts as a modulator of intracellular signaling and affects cellular proliferation and apoptosis, through its existence as a monomer or as the fifth component of the constitutive photomorphogenic-9 signalosome (CSN5). Jab1/CSN5 is involved in transcription factor specificity, deneddylation of NEDD8, and nuclear-to-cytoplasmic shuttling of key molecules. Jab1/CSN5 activities positively and negatively affect a number of pathways, including integrin signaling, cell cycle control, and apoptosis. Also, more recent studies have demonstrated the intriguing roles of Jab1/CSN5 in regulating genomic instability and DNA repair. The effects of Jab1/CSN5's multiple protein interactions are generally oncogenic in nature, and overexpression of Jab1/CSN5 in cancer provides evidence that it is involved in the tumorigenic process. In this review, we highlight our current knowledge of Jab1/CSN5 function and the recent discoveries in dissecting the Jab1 signaling pathway. Further, we also discuss the regulation of Jab1/CSN5 in cancers and its potential as a therapeutic target.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 5%
Portugal 1 2%
Germany 1 2%
Unknown 56 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 26%
Researcher 12 20%
Student > Master 8 13%
Student > Bachelor 5 8%
Student > Postgraduate 3 5%
Other 9 15%
Unknown 8 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 54%
Biochemistry, Genetics and Molecular Biology 9 15%
Medicine and Dentistry 3 5%
Immunology and Microbiology 2 3%
Neuroscience 2 3%
Other 2 3%
Unknown 10 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2010.
All research outputs
#503,237
of 3,684,317 outputs
Outputs from Cell Division
#5
of 44 outputs
Outputs of similar age
#14,008
of 85,541 outputs
Outputs of similar age from Cell Division
#1
of 2 outputs
Altmetric has tracked 3,684,317 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 44 research outputs from this source. They receive a mean Attention Score of 2.4. This one scored the same or higher as 39 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 85,541 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them