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| Title |
Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis
|
|---|---|
| Published in |
Arthritis Research & Therapy, April 2008
|
| DOI | 10.1186/ar2401 |
| Pubmed ID | |
| Authors |
Denise Richardson, Richard G Pearson, Nisha Kurian, M Liaque Latif, Michael J Garle, David A Barrett, David A Kendall, Brigitte E Scammell, Alison J Reeve, Victoria Chapman |
| Abstract |
Cannabis-based medicines have a number of therapeutic indications, including anti-inflammatory and analgesic effects. The endocannabinoid receptor system, including the cannabinoid receptor 1 (CB1) and receptor 2 (CB2) and the endocannabinoids, are implicated in a wide range of physiological and pathophysiological processes. Pre-clinical and clinical studies have demonstrated that cannabis-based drugs have therapeutic potential in inflammatory diseases, including rheumatoid arthritis (RA) and multiple sclerosis. The aim of this study was to determine whether the key elements of the endocannabinoid signalling system, which produces immunosuppression and analgesia, are expressed in the synovia of patients with osteoarthritis (OA) or RA. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 86 | 76% |
| Canada | 8 | 7% |
| Denmark | 1 | <1% |
| United Kingdom | 1 | <1% |
| Indonesia | 1 | <1% |
| Cameroon | 1 | <1% |
| Unknown | 15 | 13% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 79 | 70% |
| Members of the public | 34 | 30% |
Mendeley readers
The data shown below were compiled from readership statistics for 339 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 1% |
| United States | 4 | 1% |
| Italy | 2 | <1% |
| Canada | 2 | <1% |
| Ecuador | 1 | <1% |
| Germany | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 324 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 56 | 17% |
| Researcher | 41 | 12% |
| Student > Master | 41 | 12% |
| Student > Ph. D. Student | 36 | 11% |
| Student > Doctoral Student | 23 | 7% |
| Other | 65 | 19% |
| Unknown | 77 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 72 | 21% |
| Agricultural and Biological Sciences | 41 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 34 | 10% |
| Biochemistry, Genetics and Molecular Biology | 22 | 6% |
| Psychology | 13 | 4% |
| Other | 71 | 21% |
| Unknown | 86 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 72. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2024.
All research outputs
#635,662
of 26,434,713 outputs
Outputs from Arthritis Research & Therapy
#44
of 3,445 outputs
Outputs of similar age
#1,007
of 85,010 outputs
Outputs of similar age from Arthritis Research & Therapy
#1
of 23 outputs
Altmetric has tracked 26,434,713 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,445 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 85,010 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.