Title |
Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α
|
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Published in |
Journal of Neuroinflammation, March 2012
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DOI | 10.1186/1742-2094-9-49 |
Pubmed ID | |
Authors |
Caterina Scuderi, Marta Valenza, Claudia Stecca, Giuseppe Esposito, Maria Rosaria Carratù, Luca Steardo |
Abstract |
In addition to cytotoxic mechanisms directly impacting neurons, β-amyloid (Aβ)-induced glial activation also promotes release of proinflammatory molecules that may self-perpetuate reactive gliosis and damage neighbouring neurons, thus amplifying neuropathological lesions occurring in Alzheimer's disease (AD). Palmitoylethanolamide (PEA) has been studied extensively for its anti-inflammatory, analgesic, antiepileptic and neuroprotective effects. PEA is a lipid messenger isolated from mammalian and vegetable tissues that mimics several endocannabinoid-driven actions, even though it does not bind to cannabinoid receptors. Some of its pharmacological properties are considered to be dependent on the expression of peroxisome proliferator-activated receptors-α (PPARα). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Mexico | 1 | 1% |
United States | 1 | 1% |
Canada | 1 | 1% |
Unknown | 73 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 18% |
Student > Bachelor | 12 | 16% |
Student > Ph. D. Student | 7 | 9% |
Student > Master | 6 | 8% |
Student > Doctoral Student | 5 | 6% |
Other | 13 | 17% |
Unknown | 20 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 13% |
Biochemistry, Genetics and Molecular Biology | 10 | 13% |
Medicine and Dentistry | 8 | 10% |
Neuroscience | 6 | 8% |
Other | 7 | 9% |
Unknown | 22 | 29% |