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Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α

Overview of attention for article published in Journal of Neuroinflammation, March 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
1 news outlet
wikipedia
1 Wikipedia page

Citations

dimensions_citation
91 Dimensions

Readers on

mendeley
77 Mendeley
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Title
Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α
Published in
Journal of Neuroinflammation, March 2012
DOI 10.1186/1742-2094-9-49
Pubmed ID
Authors

Caterina Scuderi, Marta Valenza, Claudia Stecca, Giuseppe Esposito, Maria Rosaria Carratù, Luca Steardo

Abstract

In addition to cytotoxic mechanisms directly impacting neurons, β-amyloid (Aβ)-induced glial activation also promotes release of proinflammatory molecules that may self-perpetuate reactive gliosis and damage neighbouring neurons, thus amplifying neuropathological lesions occurring in Alzheimer's disease (AD). Palmitoylethanolamide (PEA) has been studied extensively for its anti-inflammatory, analgesic, antiepileptic and neuroprotective effects. PEA is a lipid messenger isolated from mammalian and vegetable tissues that mimics several endocannabinoid-driven actions, even though it does not bind to cannabinoid receptors. Some of its pharmacological properties are considered to be dependent on the expression of peroxisome proliferator-activated receptors-α (PPARα).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Mexico 1 1%
United States 1 1%
Canada 1 1%
Unknown 73 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 18%
Student > Bachelor 12 16%
Student > Ph. D. Student 7 9%
Student > Master 6 8%
Student > Doctoral Student 5 6%
Other 13 17%
Unknown 20 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 18%
Pharmacology, Toxicology and Pharmaceutical Science 10 13%
Biochemistry, Genetics and Molecular Biology 10 13%
Medicine and Dentistry 8 10%
Neuroscience 6 8%
Other 7 9%
Unknown 22 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2014.
All research outputs
#2,688,867
of 22,705,019 outputs
Outputs from Journal of Neuroinflammation
#408
of 2,612 outputs
Outputs of similar age
#17,028
of 156,371 outputs
Outputs of similar age from Journal of Neuroinflammation
#3
of 33 outputs
Altmetric has tracked 22,705,019 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,612 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,371 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.