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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Methylhonokiol attenuates neuroinflammation: a role for cannabinoid receptors?
|
|---|---|
| Published in |
Journal of Neuroinflammation, June 2012
|
| DOI | 10.1186/1742-2094-9-135 |
| Pubmed ID | |
| Authors |
Jürg Gertsch, Sharon Anavi-Goffer |
| Abstract |
The cannabinoid type-2 G protein-coupled (CB₂) receptor is an emerging therapeutic target for pain management and immune system modulation. In a mouse model of Alzheimer's disease (AD) the orally administered natural product 4'-O-methylhonokiol (MH) has been shown to prevent amyloidogenesis and progression of AD by inhibiting neuroinflammation. In this commentary we discuss an intriguing link between the recently found CB₂ receptor-mediated molecular mechanisms of MH and its anti-inflammatory and protective effects in AD animal models. We argue that the novel cannabimimetic MH may exert its beneficial effects via modulation of CB₂ receptors expressed in microglial cells and astrocytes. The recent findings provide further evidence for a potential role of CB₂ receptors in the pathophysiology of AD, spurring target validation and drug discovery. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| United Kingdom | 1 | 1% |
| Germany | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 69 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 16% |
| Researcher | 10 | 14% |
| Student > Ph. D. Student | 8 | 11% |
| Student > Bachelor | 6 | 8% |
| Student > Doctoral Student | 4 | 5% |
| Other | 9 | 12% |
| Unknown | 25 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 15% |
| Medicine and Dentistry | 10 | 14% |
| Agricultural and Biological Sciences | 9 | 12% |
| Psychology | 6 | 8% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Other | 7 | 9% |
| Unknown | 27 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2014.
All research outputs
#2,200,201
of 22,705,019 outputs
Outputs from Journal of Neuroinflammation
#305
of 2,612 outputs
Outputs of similar age
#14,421
of 163,900 outputs
Outputs of similar age from Journal of Neuroinflammation
#4
of 57 outputs
Altmetric has tracked 22,705,019 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,612 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,900 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.