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Melatonin, immune function and aging.

Overview of attention for article published in Immunity & Ageing, January 1970
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Melatonin, immune function and aging.
Published in
Immunity & Ageing, January 1970
DOI 10.1186/1742-4933-2-17
Pubmed ID

Srinivasan V, Maestroni GJ, Cardinali DP, Esquifino AI, Perumal SR, Miller SC


Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. A decrease in functional competence of individual natural killer (NK) cells is found with advancing age. Macrophages and granulocytes show functional decline in aging as evidenced by their diminished phagocytic activity and impairment of superoxide generation. There is also marked shift in cytokine profile as age advances, e.g., CD3+ and CD4+ cells decline in number whereas CD8+ cells increase in elderly individuals. A decline in organ specific antibodies occurs causing reduced humoral responsiveness. Circulating melatonin decreases with age and in recent years much interest has been focused on its immunomodulatory effect. Melatonin stimulates the production of progenitor cells for granulocytes-macrophages. It also stimulates the production of NK cells and CD4+ cells and inhibits CD8+ cells. The production and release of various cytokines from NK cells and T-helper lymphocytes also are enhanced by melatonin. Melatonin presumably regulates immune function by acting on the immune-opioid network, by affecting G protein-cAMP signal pathway and by regulating intracellular glutathione levels. Melatonin has the potential therapeutic value to enhance immune function in aged individuals and in patients in an immunocompromised state.

Mendeley readers

The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 2 2%
India 2 2%
Brazil 2 2%
Indonesia 1 <1%
United Kingdom 1 <1%
Italy 1 <1%
Mexico 1 <1%
China 1 <1%
Spain 1 <1%
Other 2 2%
Unknown 111 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 26 21%
Student > Ph. D. Student 24 19%
Student > Master 16 13%
Student > Bachelor 14 11%
Student > Doctoral Student 12 10%
Other 25 20%
Unknown 8 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 48 38%
Medicine and Dentistry 31 25%
Biochemistry, Genetics and Molecular Biology 13 10%
Immunology and Microbiology 8 6%
Social Sciences 3 2%
Other 11 9%
Unknown 11 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2013.
All research outputs
of 6,230,503 outputs
Outputs from Immunity & Ageing
of 116 outputs
Outputs of similar age
of 98,268 outputs
Outputs of similar age from Immunity & Ageing
of 7 outputs
Altmetric has tracked 6,230,503 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 116 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 98,268 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.