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Overview of attention for article published in Immunity & Ageing, January 2005
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#11 of 246)
  • High Attention Score compared to outputs of the same age (96th percentile)

Mentioned by

50 tweeters
1 Facebook page
1 video uploader


146 Dimensions

Readers on

149 Mendeley
1 CiteULike
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Published in
Immunity & Ageing, January 2005
DOI 10.1186/1742-4933-2-17
Pubmed ID

V Srinivasan, GJM Maestroni, DP Cardinali, AI Esquifino, SR Pandi Perumal, SC Miller


Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. A decrease in functional competence of individual natural killer (NK) cells is found with advancing age. Macrophages and granulocytes show functional decline in aging as evidenced by their diminished phagocytic activity and impairment of superoxide generation. There is also marked shift in cytokine profile as age advances, e.g., CD3+ and CD4+ cells decline in number whereas CD8+ cells increase in elderly individuals. A decline in organ specific antibodies occurs causing reduced humoral responsiveness. Circulating melatonin decreases with age and in recent years much interest has been focused on its immunomodulatory effect. Melatonin stimulates the production of progenitor cells for granulocytes-macrophages. It also stimulates the production of NK cells and CD4+ cells and inhibits CD8+ cells. The production and release of various cytokines from NK cells and T-helper lymphocytes also are enhanced by melatonin. Melatonin presumably regulates immune function by acting on the immune-opioid network, by affecting G protein-cAMP signal pathway and by regulating intracellular glutathione levels. Melatonin has the potential therapeutic value to enhance immune function in aged individuals and in patients in an immunocompromised state.

Twitter Demographics

The data shown below were collected from the profiles of 50 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 2 1%
India 2 1%
Brazil 2 1%
Indonesia 1 <1%
United Kingdom 1 <1%
Italy 1 <1%
Mexico 1 <1%
China 1 <1%
Spain 1 <1%
Other 2 1%
Unknown 135 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 29 19%
Student > Ph. D. Student 25 17%
Student > Master 19 13%
Student > Bachelor 19 13%
Student > Doctoral Student 12 8%
Other 30 20%
Unknown 15 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 52 35%
Medicine and Dentistry 34 23%
Biochemistry, Genetics and Molecular Biology 19 13%
Immunology and Microbiology 7 5%
Social Sciences 5 3%
Other 13 9%
Unknown 19 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 44. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2020.
All research outputs
of 16,067,273 outputs
Outputs from Immunity & Ageing
of 246 outputs
Outputs of similar age
of 155,852 outputs
Outputs of similar age from Immunity & Ageing
of 2 outputs
Altmetric has tracked 16,067,273 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 246 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,852 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them