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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Melatonin, immune function and aging
|
|---|---|
| Published in |
Immunity & Ageing, November 2005
|
| DOI | 10.1186/1742-4933-2-17 |
| Pubmed ID | |
| Authors |
V Srinivasan, GJM Maestroni, DP Cardinali, AI Esquifino, SR Pandi Perumal, SC Miller |
| Abstract |
Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. A decrease in functional competence of individual natural killer (NK) cells is found with advancing age. Macrophages and granulocytes show functional decline in aging as evidenced by their diminished phagocytic activity and impairment of superoxide generation. There is also marked shift in cytokine profile as age advances, e.g., CD3+ and CD4+ cells decline in number whereas CD8+ cells increase in elderly individuals. A decline in organ specific antibodies occurs causing reduced humoral responsiveness. Circulating melatonin decreases with age and in recent years much interest has been focused on its immunomodulatory effect. Melatonin stimulates the production of progenitor cells for granulocytes-macrophages. It also stimulates the production of NK cells and CD4+ cells and inhibits CD8+ cells. The production and release of various cytokines from NK cells and T-helper lymphocytes also are enhanced by melatonin. Melatonin presumably regulates immune function by acting on the immune-opioid network, by affecting G protein-cAMP signal pathway and by regulating intracellular glutathione levels. Melatonin has the potential therapeutic value to enhance immune function in aged individuals and in patients in an immunocompromised state. |
X Demographics
The data shown below were collected from the profiles of 57 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 11% |
| Argentina | 3 | 5% |
| Spain | 2 | 4% |
| Venezuela, Bolivarian Republic of | 2 | 4% |
| Mexico | 2 | 4% |
| Chile | 2 | 4% |
| Lebanon | 1 | 2% |
| Colombia | 1 | 2% |
| France | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 33 | 58% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 53 | 93% |
| Science communicators (journalists, bloggers, editors) | 2 | 4% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
| Scientists | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 203 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | <1% |
| India | 2 | <1% |
| Canada | 2 | <1% |
| Indonesia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Italy | 1 | <1% |
| Mexico | 1 | <1% |
| China | 1 | <1% |
| Spain | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 189 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 32 | 16% |
| Student > Ph. D. Student | 30 | 15% |
| Student > Bachelor | 26 | 13% |
| Student > Master | 19 | 9% |
| Student > Doctoral Student | 17 | 8% |
| Other | 45 | 22% |
| Unknown | 34 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 51 | 25% |
| Medicine and Dentistry | 41 | 20% |
| Biochemistry, Genetics and Molecular Biology | 29 | 14% |
| Immunology and Microbiology | 11 | 5% |
| Neuroscience | 10 | 5% |
| Other | 25 | 12% |
| Unknown | 36 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 69. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2024.
All research outputs
#629,704
of 25,726,194 outputs
Outputs from Immunity & Ageing
#21
of 452 outputs
Outputs of similar age
#1,213
of 161,779 outputs
Outputs of similar age from Immunity & Ageing
#1
of 2 outputs
Altmetric has tracked 25,726,194 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 452 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,779 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them