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DNA Methyltransferases - Role and Function

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Cover of 'DNA Methyltransferases - Role and Function'

Table of Contents

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    Book Overview
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    Chapter 1 Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges.
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    Chapter 2 DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position.
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    Chapter 3 Bacterial DNA Methylation and Methylomes.
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    Chapter 4 Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases.
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    Chapter 5 Enzymology of Mammalian DNA Methyltransferases.
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    Chapter 6 Genetic Studies on Mammalian DNA Methyltransferases.
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    Chapter 7 The Role of DNA Methylation in Cancer.
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    Chapter 8 DNA Methyltransferases - Role and Function
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    Chapter 9 DNA Methyltransferases - Role and Function
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    Chapter 10 N6-Methyladenine: A Conserved and Dynamic DNA Mark.
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    Chapter 11 Pathways of DNA Demethylation.
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    Chapter 12 Structure and Function of TET Enzymes.
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    Chapter 13 Proteins That Read DNA Methylation.
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    Chapter 14 DNA Methyltransferases - Role and Function
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    Chapter 15 DNA Methyltransferases - Role and Function
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    Chapter 16 DNA Methyltransferase Inhibitors: Development and Applications.
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    Chapter 17 DNA Methyltransferases - Role and Function
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    Chapter 18 Engineering and Directed Evolution of DNA Methyltransferases.
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    Chapter 19 DNA Labeling Using DNA Methyltransferases.
Attention for Chapter 4: Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases.
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Chapter title
Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases.
Chapter number 4
Book title
DNA Methyltransferases - Role and Function
Published in
Advances in experimental medicine and biology, November 2016
DOI 10.1007/978-3-319-43624-1_4
Pubmed ID
Book ISBNs
978-3-31-943622-7, 978-3-31-943624-1
Authors

Shoji Tajima, Isao Suetake, Kohei Takeshita, Atsushi Nakagawa, Hironobu Kimura

Editors

Albert Jeltsch, Renata Z. Jurkowska

Abstract

In mammals, three DNA methyltransferases, Dnmt1, Dnmt3a, and Dnmt3b, have been identified. Dnmt3a and Dnmt3b are responsible for establishing DNA methylation patterns produced through their de novo-type DNA methylation activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l), which is a member of the Dnmt3 family but does not possess DNA methylation activity, was reported to be indispensable for global methylation in germ cells. Once the DNA methylation patterns are established, maintenance-type DNA methyltransferase Dnmt1 faithfully propagates them to the next generation via replication. All Dnmts possess multiple domains, and in this chapter, the structures and functions of these domains are described.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 20%
Researcher 5 8%
Student > Ph. D. Student 4 7%
Student > Master 4 7%
Other 3 5%
Other 3 5%
Unknown 28 47%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 27%
Agricultural and Biological Sciences 3 5%
Medicine and Dentistry 3 5%
Nursing and Health Professions 2 3%
Neuroscience 2 3%
Other 3 5%
Unknown 30 51%