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DNA Methyltransferases - Role and Function

Overview of attention for book
Cover of 'DNA Methyltransferases - Role and Function'

Table of Contents

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    Book Overview
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    Chapter 1 Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges.
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    Chapter 2 DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position.
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    Chapter 3 Bacterial DNA Methylation and Methylomes.
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    Chapter 4 Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases.
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    Chapter 5 Enzymology of Mammalian DNA Methyltransferases.
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    Chapter 6 Genetic Studies on Mammalian DNA Methyltransferases.
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    Chapter 7 The Role of DNA Methylation in Cancer.
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    Chapter 8 DNA Methyltransferases - Role and Function
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    Chapter 9 DNA Methyltransferases - Role and Function
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    Chapter 10 N6-Methyladenine: A Conserved and Dynamic DNA Mark.
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    Chapter 11 Pathways of DNA Demethylation.
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    Chapter 12 Structure and Function of TET Enzymes.
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    Chapter 13 Proteins That Read DNA Methylation.
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    Chapter 14 DNA Methyltransferases - Role and Function
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    Chapter 15 DNA Methyltransferases - Role and Function
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    Chapter 16 DNA Methyltransferase Inhibitors: Development and Applications.
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    Chapter 17 DNA Methyltransferases - Role and Function
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    Chapter 18 Engineering and Directed Evolution of DNA Methyltransferases.
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    Chapter 19 DNA Labeling Using DNA Methyltransferases.
Attention for Chapter 3: Bacterial DNA Methylation and Methylomes.
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Chapter title
Bacterial DNA Methylation and Methylomes.
Chapter number 3
Book title
DNA Methyltransferases - Role and Function
Published in
Advances in experimental medicine and biology, November 2016
DOI 10.1007/978-3-319-43624-1_3
Pubmed ID
27826834
Book ISBNs
978-3-31-943622-7, 978-3-31-943624-1
Authors

Josep Casadesús, Casadesús, Josep

Editors

Albert Jeltsch, Renata Z. Jurkowska

Abstract

Formation of C5-methylcytosine, N4-methylcytosine, and N6-methyladenine in bacterial genomes is postreplicative and involves transfer of a methyl group from S-adenosyl-methionine to a base embedded in a specific DNA sequence context. Most bacterial DNA methyltransferases belong to restriction-modification systems; in addition, "solitary" or "orphan" DNA methyltransferases are frequently found in the genomes of bacteria and phage. Base methylation can affect the interaction of DNA-binding proteins with their cognate sites, either by a direct effect (e.g., steric hindrance) or by changes in DNA topology. In both Alphaproteobacteria and Gammaproteobacteria, the roles of DNA base methylation are especially well known for N6-methyladenine, including control of chromosome replication, nucleoid segregation, postreplicative correction of DNA mismatches, cell cycle-coupled transcription, formation of bacterial cell lineages, and regulation of bacterial virulence. Technical procedures that permit genome-wide analysis of DNA methylation are nowadays expanding our knowledge of the extent, evolution, and physiological significance of bacterial DNA methylation.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 1%
Unknown 69 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 21%
Researcher 10 14%
Student > Bachelor 10 14%
Student > Master 5 7%
Professor > Associate Professor 3 4%
Other 9 13%
Unknown 18 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 27 39%
Agricultural and Biological Sciences 11 16%
Immunology and Microbiology 6 9%
Medicine and Dentistry 6 9%
Unknown 20 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2022.
All research outputs
#15,870,020
of 23,575,346 outputs
Outputs from Advances in experimental medicine and biology
#2,579
of 5,024 outputs
Outputs of similar age
#199,515
of 314,665 outputs
Outputs of similar age from Advances in experimental medicine and biology
#47
of 84 outputs
Altmetric has tracked 23,575,346 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,024 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,665 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.

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