Chapter title |
Personalized Therapy of Small Cell Lung Cancer.
|
---|---|
Chapter number | 9 |
Book title |
Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management
|
Published in |
Advances in experimental medicine and biology, December 2015
|
DOI | 10.1007/978-3-319-24932-2_9 |
Pubmed ID | |
Book ISBNs |
978-3-31-924931-5, 978-3-31-924932-2
|
Authors |
Schneider, Bryan J, Kalemkerian, Gregory P, Bryan J. Schneider M.D., Gregory P. Kalemkerian M.D., Bryan J. Schneider, Gregory P. Kalemkerian |
Editors |
Aamir Ahmad, Shirish M. Gadgeel |
Abstract |
Small cell lung cancer (SCLC) is an aggressive, poorly differentiated neuroendocrine carcinoma with distinct clinical, pathological and molecular characteristics. Despite robust responses to initial chemotherapy and radiation, the prognosis of patients with SCLC remains poor with an overall 5-year survival rate of less than 10 %. Despite the fact that numerous molecularly targeted approaches have thus far failed to demonstrate clinical utility in SCLC, further advances will rely on better definition of the biological pathways that drive survival, proliferation and metastasis. Recent next-generation, molecular profiling studies have identified many new therapeutic targets in SCLC, as well as extreme genomic instability which explains the high degree of resistance. A wide variety of anti-angiogenic agents, growth factor inhibitors, pro-apoptotic agents, and epigenetic modulators have been evaluated in SCLC and many studies of these strategies are on-going. Perhaps the most promising approaches involve agents targeting cancer stem cell pathways and immunomodulatory drugs that interfere with the PD1 and CTLA-4 pathways. SCLC offers many barriers to the development of successful therapy, including limited tumor samples, inadequate preclinical models, high mutational burden, and aggressive tumor growth which impairs functional status and hampers enrollment on clinical trials. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 22% |
Student > Doctoral Student | 6 | 13% |
Researcher | 6 | 13% |
Other | 5 | 11% |
Student > Master | 4 | 9% |
Other | 6 | 13% |
Unknown | 8 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 47% |
Biochemistry, Genetics and Molecular Biology | 6 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Agricultural and Biological Sciences | 2 | 4% |
Nursing and Health Professions | 2 | 4% |
Other | 3 | 7% |
Unknown | 9 | 20% |