Title |
Clustering protein environments for function prediction: finding PROSITE motifs in 3D
|
---|---|
Published in |
BMC Bioinformatics, May 2007
|
DOI | 10.1186/1471-2105-8-s4-s10 |
Pubmed ID | |
Authors |
Sungroh Yoon, Jessica C Ebert, Eui-Young Chung, Giovanni De Micheli, Russ B Altman |
Abstract |
Structural genomics initiatives are producing increasing numbers of three-dimensional (3D) structures for which there is little functional information. Structure-based annotation of molecular function is therefore becoming critical. We previously presented FEATURE, a method for describing microenvironments around functional sites in proteins. However, FEATURE uses supervised machine learning and so is limited to building models for sites of known importance and location. We hypothesized that there are a large number of sites in proteins that are associated with function that have not yet been recognized. Toward that end, we have developed a method for clustering protein microenvironments in order to evaluate the potential for discovering novel sites that have not been previously identified. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 13% |
Korea, Republic of | 1 | 3% |
Unknown | 26 | 84% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 39% |
Student > Ph. D. Student | 8 | 26% |
Professor > Associate Professor | 3 | 10% |
Professor | 2 | 6% |
Student > Master | 2 | 6% |
Other | 1 | 3% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 29% |
Computer Science | 9 | 29% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Medicine and Dentistry | 2 | 6% |
Engineering | 2 | 6% |
Other | 3 | 10% |
Unknown | 3 | 10% |