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Mendeley readers
Attention Score in Context
| Title |
Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid
|
|---|---|
| Published in |
Acta Neuropathologica Communications, November 2016
|
| DOI | 10.1186/s40478-016-0390-8 |
| Pubmed ID | |
| Authors |
Blaine R. Roberts, James D. Doecke, Alan Rembach, L. Fernanda Yévenes, Christopher J. Fowler, Catriona A. McLean, Monica Lind, Irene Volitakis, Colin L. Masters, Ashley I. Bush, Dominic J. Hare, the AIBL research group |
| Abstract |
Loss of intracellular compartmentalization of potassium is a biochemical feature of Alzheimer's disease indicating a loss of membrane integrity and mitochondrial dysfunction. We examined potassium and rubidium (a biological proxy for potassium) in brain tissue, blood fractions and cerebrospinal fluid from Alzheimer's disease and healthy control subjects to investigate the diagnostic potential of these two metal ions. We found that both potassium and rubidium levels were significantly decreased across all intracellular compartments in the Alzheimer's disease brain. Serum from over 1000 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL), showed minor changes according to disease state. Potassium and rubidium levels in erythrocytes and cerebrospinal fluid were not significantly different according to disease state, and rubidium was slightly decreased in Alzheimer's disease patients compared to healthy controls. Our data provides evidence that contrasts the hypothesized disruption of the blood-brain barrier in Alzheimer's disease, with the systemic decrease in cortical potassium and rubidium levels suggesting influx of ions from the blood is minimal and that the observed changes are more likely indicative of an internal energy crisis within the brain. These findings may be the basis for potential diagnostic imaging studies using radioactive potassium and rubidium tracers. |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 63 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 24% |
| Researcher | 7 | 11% |
| Student > Bachelor | 5 | 8% |
| Other | 5 | 8% |
| Student > Doctoral Student | 4 | 6% |
| Other | 11 | 17% |
| Unknown | 16 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 19% |
| Neuroscience | 8 | 13% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Social Sciences | 3 | 5% |
| Agricultural and Biological Sciences | 2 | 3% |
| Other | 11 | 17% |
| Unknown | 23 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2021.
All research outputs
#3,415,215
of 25,774,185 outputs
Outputs from Acta Neuropathologica Communications
#646
of 1,596 outputs
Outputs of similar age
#53,068
of 314,342 outputs
Outputs of similar age from Acta Neuropathologica Communications
#6
of 21 outputs
Altmetric has tracked 25,774,185 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,596 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,342 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.