Raynaud’s Phenomenon: A Brief Review of the Underlying Mechanisms

https://t.co/jO6t8fYb4u "This cooling-induced Rho activation may then act through calcium sensitization or via modulation of cytoskeletal architecture."

https://t.co/jO6t8fYb4u "Indeed, upon cold stress, it is the mitochondria that initiate the process by releasing ROS, which in turn triggers a redox signal that activates the Rho/Rho kinase pathway leading to spatial redistribution and functional activati

https://t.co/jO6t8fYb4u "However, additional and rather elegant investigations from the Flavahan group further showed that the mitochondrion is the “thermo-sensitive” organelle in VSMCs."

https://t.co/jO6t8fYb4u "The now active Rho evokes the mobilization of α2C-AR to the membrane, and consequently triggers cold-induced vasoconstriction." "In this sense, it seems that Rho, rather than α2C-AR, is the “thermosensor”."